| Animal Research: |
| Carbohydrate Research,1966,2(4): 272-288. | | The isolation of some heptoses, heptuloses, octuloses, and nonuloses from primula officinalis jacq.[Reference: WebLink] |
METHODS AND RESULTS:
An aqueous extract of 20 kg of the dried roots of Primula officinalis Jacq. has been deproteinized, deionized, fermented with bakers' yeast, and fractionated by chromatography on cellulose columns, Dowex 50W-X8 (Ba2+) resin columns, and sheets of filter paper. The following higher-carbon sugars were isolated: D-altro-heptulose (sedoheptulose), D-manno-heptulose, D-allo-heptulose, D-altro-3-heptulose, D-glycero-D-manno-heptose, D-glycero-D-gluco-heptose, D-glycero-D-manno-octulose, D-glycero-L-galacto-octulose, D-erythro-L-gluco-nonulose, and D-erythro-L-galacto-nonulose.
Two higher-carbon polyhydric alcohols —volemitol (D-glycero-D-manno-heptitol) and β-sedoheptitol (D-glycero-D-gluco-heptitol)—were also isolated, as well as glycerol, erythritol, xylitol, myo-inositol, D-xylose, and primeverose.
CONCLUSIONS:
Of all these substances, only volemitol had previously been isolated from P. officinalis, although primeverose was known to occur there as a constituent of the glycosides primeverin and Primulaverin. In addition, primeverose has been reduced to primeveritol (6-O-β-D-xylopyranosyl-D-glucitol), which was characterized further as the crystalline octaacetate; and the crystalline D-glycero-β-D-gluco-heptose has been converted into the new, crystalline D-glycero-β-D-gluco-heptose hexaacetate. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)