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Pseurotin A
Pseurotin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Pseurotin A
Price:
CAS No.: 58523-30-1
Catalog No.: CFN96943
Molecular Formula: C22H25NO8
Molecular Weight: 431.44 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The cultures of marine Bacillus sp. FS8D.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively. Pseurotin A shows to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 uM, the targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A.
Targets: Antifection | Immunology & Inflammation related
In vitro:
Z Naturforsch C. 2008 May-Jun;63(5-6):383-8.
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii.[Pubmed: 18669024]
Penicillium janczewskii K. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina.
METHODS AND RESULTS:
When grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. The compounds were for the first time isolated from this species and identified by spectroscopic methods as Pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic peptides by endophytic fungi from Chilean gymnosperms.
CONCLUSIONS:
Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively.
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1457-60.
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.[Pubmed: 19179074 ]

METHODS AND RESULTS:
A natural product, Pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of Pseurotin A was performed.
CONCLUSIONS:
Structure-activity relationship studies of Pseurotin Analogues elucidated that 10-deoxyPseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.
Pseurotin A Description
Source: The cultures of marine Bacillus sp. FS8D.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3178 mL 11.5891 mL 23.1782 mL 46.3564 mL 57.9455 mL
5 mM 0.4636 mL 2.3178 mL 4.6356 mL 9.2713 mL 11.5891 mL
10 mM 0.2318 mL 1.1589 mL 2.3178 mL 4.6356 mL 5.7945 mL
50 mM 0.0464 mL 0.2318 mL 0.4636 mL 0.9271 mL 1.1589 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.4636 mL 0.5795 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Nat Prod Res. 2017 Jun 23:1-4.
Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.[Pubmed: 28641457]

METHODS AND RESULTS:
Pseurotin A was isolated from a culture of marine Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 μM. It has been found that Pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation.
CONCLUSIONS:
The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of Pseurotin A.
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