Science | Nature | Cell | View More
Natural Products
Sanguinarine chloride
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Sanguinarine chloride
Price: $30 / 20mg
CAS No.: 5578-73-4
Catalog No.: CFN80234
Molecular Formula: C20H14NO4.Cl
Molecular Weight: 367.79 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Chelidonium majus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $10.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • The Australian National University (Australia)
  • Korea Institute of Oriental Med... (Korea)
  • Tokyo Woman's Christian University (Japan)
  • University of Fribourg (Switzerland)
  • Seoul National University (Korea)
  • Research Unit Molecular Epigene... (Germany)
  • Universite de Lille1 (France)
  • Srinakharinwirot University (Thailand)
  • Universit?t Basel (Switzerland)
  • Universidade Federal de Goias (... (Brazil)
  • Instituto de Investigaciones Ag... (Chile)
  • More...
Package
Featured Products
Alpha-pinene

Catalog No: CFN93285
CAS No: 80-56-8
Price: $30/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg
Polyporenic acid C

Catalog No: CFN92739
CAS No: 465-18-9
Price: $268/10mg
Valerenic acid

Catalog No: CFN70254
CAS No: 3569-10-6
Price: $ / mg
Zerumbone

Catalog No: CFN91066
CAS No: 471-05-6
Price: $70/20mg
Lobetyolin

Catalog No: CFN99104
CAS No: 136085-37-5
Price: $168/20mg
Angustifoline

Catalog No: CFN92233
CAS No: 550-43-6
Price: $490/5mg
Capsaicin

Catalog No: CFN99917
CAS No: 404-86-4
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Sanguinarine chloride is a novel class of anti-Salmonella compounds, it could decrease the production of the SPI-1 type III secretion system main virulence proteins SipA and SipB and prevent the invasion of HeLa cells by Salmonella enterica serovar Typhimurium without affecting the growth of Salmonella. Sanguinarine chloride also shows cytotoxicity to cultured human cells from oral tissue.
Targets: Antifection
In vitro:
Biochemistry & Biophysics Reports, 2018, 14:149–154.
Natural compound sanguinarine chloride targets the type III secretion system of Salmonella enterica Serovar Typhimurium[Reference: WebLink]
The type III secretion system (T3SS) is a key virulence mechanism of many Gram-negative bacterial pathogens. Upon contact between bacteria and host cells, T3SS transfers a series of effectors from the bacterial cytosol to host cells. It is widely known that a mutation in T3SS does not impair bacterial growth, thereby avoiding any subsequent development of resistance. Thus, T3SS is expected to be a candidate therapeutic target.
METHODS AND RESULTS:
While developing the T3SS screening method, we discovered that Sanguinarine chloride, a natural compound, could decrease the production of the SPI-1 type III secretion system main virulence proteins SipA and SipB and prevent the invasion of HeLa cells by Salmonella enterica serovar Typhimurium without affecting the growth of Salmonella. Furthermore, Sanguinarine chloride downregulated the transcription of HilA and consequently regulated the expression of the SPI-1 apparatus and effector genes.
CONCLUSIONS:
In summary, our study directly demonstrated that this putative SPI-1 inhibitor belongs to a novel class of anti-Salmonella compounds.
Pharmacol Toxicol. 1996 Jun;78(6):397-403.
Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue.[Pubmed: 8829200]

METHODS AND RESULTS:
The in vitro cytotoxicity of Sanguinarine chloride, a dental product used in the treatment of gingivitis and plaque, was compared using cell lines and primary cells from oral human tissues. For the established cell lines, Sanguinarine chloride exhibited similar potencies to S-G gingival epithelial cells and to KB carcinoma cells, whereas HGF-1 gingival fibroblasts were more tolerant. However, a gingival primary cell culture was more sensitive to Sanguinarine chloride than were the established cell lines. Detailed studies were performed with the S-G cells. The 24-hr midpoint (NR50) cytotoxicity value towards the S-G cells was 7.6 microM, based on the neutral red cytotoxicity assay; vacuolization and multinucleation were noted. When exposed to Sanguinarine chloride for 3 days, a lag in growth kinetics was first observed at 1.7 microM. Damage to the integrity of the plasma membrane was evident, as leakage of lactic acid dehydrogenase occurred during a 3 hr exposure to Sanguinarine chloride at 0.1275 mM and greater.
CONCLUSIONS:
The cytotoxicity of Sanguinarine chloride to the S-G cells was lessened in the presence of an S9 hepatic microsomal fraction from Aroclor-induced rats or by including fetal bovine serum (15%) in the exposure medium. Progressively increasing the pH from 6.0 to 7.8 enhanced the potency of Sanguinarine chloride, presumably due to the enhanced uptake of the lipophilic alkanolamine form, as compared to that of the cationic iminium form.
Sanguinarine chloride Description
Source: The herbs of Chelidonium majus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Alopecurone A

Catalog No: CFN95512
CAS No: 162558-89-6
Price: $318/10mg
New compound 8

Catalog No: CFN95341
CAS No: N/A
Price: $318/5mg
Gossypetin 3-sophoroside-8-glucosi...

Catalog No: CFN95528
CAS No: 77306-93-5
Price: $318/5mg
Rhamnetin 3-galactoside

Catalog No: CFN95116
CAS No: 62858-07-5
Price: $318/5mg
Scoparin

Catalog No: CFN95544
CAS No: 301-16-6
Price: $318/5mg
Kaempferol 3,5-O-diglucoside

Catalog No: CFN95487
CAS No: 205103-97-5
Price: $318/5mg
Ganoderic acid beta

Catalog No: CFN95537
CAS No: 217476-76-1
Price: $413/5mg
Glicoricone

Catalog No: CFN95063
CAS No: 161099-37-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7189 mL 13.5947 mL 27.1894 mL 54.3789 mL 67.9736 mL
5 mM 0.5438 mL 2.7189 mL 5.4379 mL 10.8758 mL 13.5947 mL
10 mM 0.2719 mL 1.3595 mL 2.7189 mL 5.4379 mL 6.7974 mL
50 mM 0.0544 mL 0.2719 mL 0.5438 mL 1.0876 mL 1.3595 mL
100 mM 0.0272 mL 0.1359 mL 0.2719 mL 0.5438 mL 0.6797 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Alpha-pinene

Catalog No: CFN93285
CAS No: 80-56-8
Price: $30/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg
Polyporenic acid C

Catalog No: CFN92739
CAS No: 465-18-9
Price: $268/10mg
Valerenic acid

Catalog No: CFN70254
CAS No: 3569-10-6
Price: $ / mg
Zerumbone

Catalog No: CFN91066
CAS No: 471-05-6
Price: $70/20mg
Lobetyolin

Catalog No: CFN99104
CAS No: 136085-37-5
Price: $168/20mg
Angustifoline

Catalog No: CFN92233
CAS No: 550-43-6
Price: $490/5mg
Capsaicin

Catalog No: CFN99917
CAS No: 404-86-4
Price: $50/20mg
Tags: buy Sanguinarine chloride | Sanguinarine chloride supplier | purchase Sanguinarine chloride | Sanguinarine chloride cost | Sanguinarine chloride manufacturer | order Sanguinarine chloride | Sanguinarine chloride distributor