Schisanlactone E | CAS:136040-43-2 | Manufacturer ChemFaces

Schisanlactone E

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Description:

Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.

Targets:

In vitro:

Fitoterapia. 2014 Dec;99:352-61.

Bioactive metabolites of Schisanlactone E transformed by Cunninghamella blakesleana AS 3.970.[Pubmed: 25451796]

Schisanlactone E (SE) is a major triterpene obtained from the plants of genus Kadsura. The aim of this research was to investigate the transformed metabolites of Schisanlactone E by fungi and evaluate the bioactivities of these products.
METHODS AND RESULTS:
After screening 10 strains of filamentous fungi, Cunninghamella blakesleana AS 3.970 was chosen as a potent organism to be used for the biotransformation of Schisanlactone E. 13 metabolites were obtained and determined to be new compounds through the use of spectroscopic data, including UV, 1D-, 2D-NMR, and HR-ESIMS.
CONCLUSIONS:
Furthermore, in an in vitro bioassay, metabolites 7 and 9 showed moderate inhibitory effects on the nitric oxide production in LPS-induced macrophages with IC50 values of 16.73, 5.91 μM, respectively; 9 could inhibit the proliferation of acetaldehyde-induced HSC-T6 cells, with the IC50 value of 21.4 μM. Preliminary findings on the structure-activity relationships for these metabolites were also discussed.

Schisanlactone E Description

Source:	The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Med. 2006 Apr;72(5):450-7.

New triterpenoids from Kadsura heteroclita and their cytotoxic activity.[Pubmed: 16557460 ]

METHODS AND RESULTS:
Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A-E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time from a natural source, and the six known compounds Schisanlactone E (8), cycloartenone (9), schisandronic acid (10), nigranoic acid (11), changnanic acid (12) and schisanlactone B (13), respectively. The structures of these compounds were characterized by extensive 1D and 2D NMR spectral analyses.
METHODS AND RESULTS:
The majority of these triterpenoids showed moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60. Among the compounds tested, heteroclitalactone D (4) showed the strongest cytotoxic activity against the HL-60 cells with an IC50 of 6.76 microM.

Product Name	Schisanlactone E
Price:
CAS No.:	136040-43-2
Catalog No.:	CFN90451
Molecular Formula:	C₃₀H₄₄O₄
Molecular Weight:	468.67 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Cryst.
Source:	The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Triterpenoids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1337 mL	10.6685 mL	21.337 mL	42.6739 mL	53.3424 mL
5 mM	0.4267 mL	2.1337 mL	4.2674 mL	8.5348 mL	10.6685 mL
10 mM	0.2134 mL	1.0668 mL	2.1337 mL	4.2674 mL	5.3342 mL
50 mM	0.0427 mL	0.2134 mL	0.4267 mL	0.8535 mL	1.0668 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.4267 mL	0.5334 mL

CFN97492	Secaubrytriol	925932-10-1	490.7	C₃₀H₅₀O₅
CFN96745	24-Hydroxy-25-ethoxy-3,4-secocycloart-4(28)-en-3-oic acid methyl ester	1392210-81-9	516.80	C₃₃H₅₆O₄
CFN98318	Coronalolic acid	268214-52-4	470.7	C₃₀H₄₆O₄
CFN89388	Gardenoin J	1345109-46-7	488.69	C₃₀H₄₈O₅
CFN99255	Sootepin D	1154518-97-4	484.7	C₃₁H₄₈O₄
CFN98317	Coronalolide	268214-51-3	482.7	C₃₀H₄₂O₅
CFN98316	Coronalolide methyl ester	268214-50-2	496.7	C₃₁H₄₄O₅
CFN89422	26-O-Acetylsootepin A	1772588-99-4	540.73	C₃₃H₄₈O₆
CFN90253	Nigranoic acid	39111-07-4	470.69	C₃₀H₄₆O₄
CFN90451	Schisanlactone E	136040-43-2	468.67	C₃₀H₄₄O₄