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Scutebarbatine B
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Product Name Scutebarbatine B
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CAS No.: 905929-95-5
Catalog No.: CFN97471
Molecular Formula: C33H35NO7
Molecular Weight: 557.6 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Scutellaria barbata D. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 uM against K562 cell lines and HL60 cell lines.
In vitro:
J Asian Nat Prod Res. 2013 Sep;15(9):941-9.
Bioassay-guided isolation of neo-clerodane diterpenoids from Scutellaria barbata.[Pubmed: 23909895]

METHODS AND RESULTS:
Bioassay-guided isolation of the aerial part of Scutellaria barbata yielded three new neo-clerodane diterpenoids scutebatas P-R (1-3), together with two known ones: scutebata E (4) and Scutebarbatine B (5). The chemical structures of the isolated compounds were elucidated by spectroscopic methods (NMR and MS) and by comparison with the spectroscopic data reported in the literature.
CONCLUSIONS:
All compounds except 3 showed weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines, and compounds 1, 2, and 5 also displayed weak activities against HL60 cell lines.
Scutebarbatine B Description
Source: The herbs of Scutellaria barbata D. Don.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7934 mL 8.967 mL 17.934 mL 35.868 mL 44.835 mL
5 mM 0.3587 mL 1.7934 mL 3.5868 mL 7.1736 mL 8.967 mL
10 mM 0.1793 mL 0.8967 mL 1.7934 mL 3.5868 mL 4.4835 mL
50 mM 0.0359 mL 0.1793 mL 0.3587 mL 0.7174 mL 0.8967 mL
100 mM 0.0179 mL 0.0897 mL 0.1793 mL 0.3587 mL 0.4484 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2015 Jan;40(1):98-102.
Diterpenoids from Scutellaria strigillosa.[Pubmed: 25993796]

METHODS AND RESULTS:
By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, nine diterpenoids were isolated and purified from the whole plants of Scutellaria strigillosa. Based on the physico-chemical properties and spectral data, their structures were elucidated as: 6-O-acetyl-7-O-nicotinoylscutebarbatine G(1), 6-O-nicotinoyl-7-O-acetylscutebarbatine G(2), 6,7-di-O-nicotinoylscutebarbatine G(3), scutebarbatine K(4), Scutebarbatine B(5), 6-O-acetylscutehenanine A(6), 6-O-nicotinoylbarba- tin A(7), 6,7-di-O-acetoxylbarbatin A(8), scutebarbatine F(9).
CONCLUSIONS:
Compound 1 is a new diterpenoid, and compounds 2-9 were isolated from Scutellaria strigillosa for the first time.
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