| Structure Identification: |
| Zhongguo Zhong Yao Za Zhi. 2016 Sep;41(18):3366-3370. | | neo-Clerodane diterpenoids from Scutellaria galericulata.[Pubmed: 28925119] |
METHODS AND RESULTS:
By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, fourteen diterpenoids were isolated and purified from the whole plants of Scutellaria galericulata. Based on the physico-chemical properties and spectral data, their structures were elucidated and identified as：scutebarbatine D(1), scutolide A(2), scutolide K(3), scutebata J(4), scutebata I(5), 6-O-acetylscutehenanine A(6), barbatin C(7), scutolide E(8), barbatine C(9), Scutebarbatine Y(10), scutebarbatine B(11), scutestrigillosin A(12), scutebata O(13), scutolide B(14).
CONCLUSIONS:
Compounds 1-14 were isolated from S. galericulata for the first time. | | Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1267-70. | | Scutebarbatines W-Z, new neo-clerodane diterpenoids from Scutellaria barbata and structure revision of a series of 13-spiro neo-clerodanes.[Pubmed: 20823615] | | Four new neo-clerodane diterpenoids, scutebarbatine W, scutebarbatine X, Scutebarbatine Y, scutebarbatine Z (1-4), were isolated from the ethanol extract of Scutellaria barbata (Labiatae), and their structures were elucidated on the basis of extensive spectroscopic studies. In addition, the proposed structures of at least seven 13-spiro subtype neo-clerodanes: scutehenanine B (5), scutebarbatine G (6), 6-O-nicotinoylscutebarbatine G (7), barbatin A (8), 6,7-di-O-nicotinoylscutebarbatine G (9), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (10), and scutebarbatine F (11), reported by Dai and co-workers from the same species, were incorrectly assigned and have been revised by reanalysis of the published NMR data. |
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