Shatavarin IV | CAS:84633-34-1 | Manufacturer ChemFaces

Shatavarin IV

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Shatavarin IV shows in vitro anti-malassezia activity. Shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models.

In vitro:

International journal of cosmetic ence, 2013, 36(1):74-78.

In vitro Anti-Malassezia Activity and Potential Use in Anti-dandruff Formulation of Asparagus racemosus.[Reference: WebLink]

Malassezia species are frequently associated with dandruff and seborrhoeic dermatitis. The study was conducted to evaluate anti-fungal activities of the extracts obtained from the roots of Asparagus racemosus Willd against Malassezia furfur and M. globosa.
METHODS AND RESULTS:
Asparagus racemosus roots were successively extracted with the series of solvents, that is, hexane, ethanol and water, and also a saponin-enriched fraction was prepared. The amounts of saponin (equivalent to Shatavarin IV) in the extracts were determined using ELISA. The extracts were tested for anti-fungal activity by disc diffusion and broth microdilution methods. By disc diffusion, only the ethanolic and saponin-enriched extracts demonstrated anti-fungal activity against M. furfur and M. globosa at the concentration of 1 mg per disc whereas the extracts with other solvents were ineffective. Multiple concentrations using the broth microdilution method against M. furfur and M. globosa yielded minimum inhibitory concentrations (MICs) of 25 mg mL(-1) for the ethanolic extract but much higher potency for the saponin-enriched extract: MICs to 0.20 and 0.40 mg mL(-1) for M. furfur and M. globosa, respectively. These extracts showed no antagonist effect with the anti-fungal agents, ketoconazole and zinc pyrithione.
CONCLUSIONS:
These studies revealed the antifungal activity of A. racemosus roots extracts. Because A. racemosus is also anti-inflammatory agent, it has the potential use as an active ingredient in an anti-dandruff formulation.

In vivo:

Indian Journal of Pharmacology, 2012, 44(6):732.

Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus.[Reference: WebLink]

The anticancer activity of shatavarins (containing Shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro and in vivo experimental models.
METHODS AND RESULTS:
The Shatavarin IV was isolated from ethyl acetate insoluble fraction (AR-2B) of chloroform:methanol (2:1) (AR-2) extract of A. racemosus roots. The cytotoxicity (in vitro) of Shatavarin IV and other shatavarins rich fraction was carried out using of MTT assay using MCF-7 (human breast cancer), HT-29 (human colon adenocarcinoma), and A-498 (human kidney carcinoma) cell lines. The in vivo anticancer activity of shatavarins (containing Shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice. The isolated Shatavarin IV (84.69 %) along with shatavarins rich fraction, coded AR-2B containing 5.05% Shatavarin IV showed potent cytotoxicity. Oral administration of AR-2B to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days, showed significant reduction in percent increase in body weight, tumor volume, packed cell volume, viable tumor cell count, and increased non-viable cell count when compared to the untreated mice of the EAC control group. The restoration of hematological parameters towards normalcy was also observed.
CONCLUSIONS:
The result suggests that the shatavarins (containing Shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models.

Shatavarin IV Description

Source:	The roots of Asparagus racemosus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Shatavarin IV
Price:
CAS No.:	84633-34-1
Catalog No.:	CFN70458
Molecular Formula:	C₄₅H₇₄O₁₇
Molecular Weight:	887.1 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The roots of Asparagus racemosus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1273 mL	5.6363 mL	11.2727 mL	22.5454 mL	28.1817 mL
5 mM	0.2255 mL	1.1273 mL	2.2545 mL	4.5091 mL	5.6363 mL
10 mM	0.1127 mL	0.5636 mL	1.1273 mL	2.2545 mL	2.8182 mL
50 mM	0.0225 mL	0.1127 mL	0.2255 mL	0.4509 mL	0.5636 mL
100 mM	0.0113 mL	0.0564 mL	0.1127 mL	0.2255 mL	0.2818 mL

CFN99055	Mannioside A	1038922-95-0	738.9	C₃₉H₆₂O₁₃
CFN90638	Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	128502-94-3	754.9	C₃₉H₆₂O₁₄
CFN95776	25(27)-Ene-elephanoside H	1592406-40-0	752.9	C₃₉H₆₀O₁₄
CFN70458	Shatavarin IV	84633-34-1	887.1	C₄₅H₇₄O₁₇
CFN90636	14-Hydroxy sprengerinin C	1111088-89-1	871.02	C₄₄H₇₀O₁₇
CFN90614	17-Hydroxy sprengerinin C	1029017-75-1	871.02	C₄₄H₇₀O₁₇
CFN96366	Sprengerinin C	88861-91-0	855.0	C₄₄H₇₀O₁₆
CFN96364	2''-O-Acetylsprengerinin C	1220707-33-4	897.1	C₄₆H₇₂O₁₇
CFN92807	Glucopyranoside,(3beta,25R)-17-hydroxyspirost-5-en-3-yl	84914-58-9	870.5	C₄₄H₇₀O₁₇
CFN90701	Polyphyllin H	81917-50-2	871.0	C₄₄H₇₀O₁₇