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Sorokinianin
Sorokinianin
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Product Name Sorokinianin
Price:
CAS No.: 162616-73-1
Catalog No.: CFN96670
Molecular Formula: C18H28O4
Molecular Weight: 308.42 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The culture filtrates of the fungus Drechslera cynodontis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Sorokinianin is a phytotoxin, it has antifungal activity, it is highly effective in suppressing spore germination of F. solani (75%) at 100 ug/ml concentration.
Targets: Antifection
In vitro:
Mansoura University Journal of Agricultural Sciences, 2009.
Fungitoxic activity of two sequiterpene compounds from drechslera cynodontis against plant pathogen fungi.[Reference: WebLink]

METHODS AND RESULTS:
Two, sesquiterpenes; Dihydrobipolaroxin (1) and Sorokinianin (2). have been isolated from the culture filtrates of the fungus Drechslera cynodontis.Compound 2 (Sorokinianin) decreased the fungal growth at concentration of 100 μg/ml in all tested fungi which ranged from 22.2% growth inhibition in R. solani to 61.1% in F. solani. Compound 2 was highly effective in suppressing spore germination of F. solani (75%) at 100μg/ml concentration. Data of experiments done to determine the minimum inhibitory concentrations (MIC) for fungal growth indicated that maximum concentration (100 μg/ml) of both compounds was not sufficient for inhibiting completely the growth of all tested fungi.
CONCLUSIONS:
All tested compounds recorded higher MIC values (100 μg/ml). The MIC for spore germination Compounds 1 and compounds 2 had less inhibitory effect on spore germination of all tested fungi, they recorded- higher MIC values (100 μg/ml).
Sorokinianin Description
Source: The culture filtrates of the fungus Drechslera cynodontis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2423 mL 16.2117 mL 32.4233 mL 64.8466 mL 81.0583 mL
5 mM 0.6485 mL 3.2423 mL 6.4847 mL 12.9693 mL 16.2117 mL
10 mM 0.3242 mL 1.6212 mL 3.2423 mL 6.4847 mL 8.1058 mL
50 mM 0.0648 mL 0.3242 mL 0.6485 mL 1.2969 mL 1.6212 mL
100 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.6485 mL 0.8106 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron Letters, 1994, 35(51):9597-9600.
Sorokinianin: A novel phytotoxin produced by the phytopathogenic fungus Bipolaris sorokiniana[Reference: WebLink]

METHODS AND RESULTS:
Structure of Sorokinianin, a novel phytotoxin from an isolate of Bipolaris sorokiniana was determined to be 3-hydroxy-5-(8′-hydroxymethyl-4′-isopropyl-1′-methyl-7′-methylenebicyclo[3.2.1]oct-6′-yl)tetrahydro-2-furanone predominantly on the basis of 2D NMR.
CONCLUSIONS:
The preliminary incorporation study suggested that this phytotoxin is derived biogenetically not from a geranylgeranylpyrophosphate through removal of two carbons but from a farnesylpyrophosphate and an additional C3 unit.
CFN89167Isosativenediol57079-92-2236.35C15H24O2
CFN96986Dihydroprehelminthosporol118069-95-7238.37C15H26O2
CFN96987Prehelminthosporolactone118101-72-7234.33C15H22O2
CFN89156Prehelminthosporol1619-13-2236.35C15H24O2
CFN96670Sorokinianin162616-73-1308.42C18H28O4
CFN96681Secolongifolenediol53587-37-4238.37C15H26O2
CFN89278Drechslerine A405157-84-8224.34C14H24O2
CFN89215Drechslerine D405157-88-2250.33C15H22O3
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