Sucralose | CAS:56038-13-2 | Manufacturer ChemFaces

Sucralose

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $10.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Sucralose, an intense artificial sweetener, may induce neurological and oxidative mechanisms with potentially important consequences for animal behaviour and physiology.

Targets:

AchR

In vitro:

PLoS ONE, 2014, 9(4):e92771.

Sucralose Induces Biochemical Responses in Daphnia magna[Pubmed: 24699280 ]

The intense artificial sweetener Sucralose has no bioconcentration properties, and no adverse acute toxic effects have been observed in standard ecotoxicity tests, suggesting negligible environmental risk. However, significant feeding and behavioural alterations have been reported in non-standard tests using aquatic crustaceans, indicating possible sublethal effects.
METHODS AND RESULTS:
We hypothesized that these effects are related to alterations in acetylcholinesterase (AChE) and oxidative status in the exposed animals and investigated changes in AChE and oxidative biomarkers (oxygen radical absorbing capacity, ORAC, and lipid peroxidation, TBARS) in the crustacean Daphnia magna exposed to Sucralose (0.0001-5 mg L-1). The Sucralose concentration was a significant positive predictor for ORAC, TBARS and AChE in the daphnids. Moreover, the AChE response was linked to both oxidative biomarkers, with positive and negative relationships for TBARS and ORAC, respectively.
CONCLUSIONS:
These joint responses support our hypothesis and suggest that exposure to Sucralose may induce neurological and oxidative mechanisms with potentially important consequences for animal behaviour and physiology.

Sucralose Description

Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Sucralose
Price:	$40 / 20mg
CAS No.:	56038-13-2
Catalog No.:	CFN93356
Molecular Formula:	C₁₂H₁₉Cl₃O₈
Molecular Weight:	397.6 g/mol
Purity:	>=98%
Type of Compound:	Saccharides
Physical Desc.:	Powder
Source:
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5151 mL	12.5755 mL	25.1509 mL	50.3018 mL	62.8773 mL
5 mM	0.503 mL	2.5151 mL	5.0302 mL	10.0604 mL	12.5755 mL
10 mM	0.2515 mL	1.2575 mL	2.5151 mL	5.0302 mL	6.2877 mL
50 mM	0.0503 mL	0.2515 mL	0.503 mL	1.006 mL	1.2575 mL
100 mM	0.0252 mL	0.1258 mL	0.2515 mL	0.503 mL	0.6288 mL

CFN95240	Platycogenin A	1459719-53-9	829.0	C₄₂H₆₈O₁₆
CFN00371	Grantaline	83482-61-5	351.40	C₁₈H₂₅NO₆
CFN92122	1-Acetyl-beta-carboline	50892-83-6	210.2	C₁₃H₁₀N₂O
CFN60290	GSK-J4	1373423-53-0	417.50	C₂₄H₂₇N₅O₂