Silydianin | CAS:29782-68-1 | Manufacturer ChemFaces

Silydianin

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Product Name	Silydianin
Price:	$168 / 20mg
CAS No.:	29782-68-1
Catalog No.:	CFN90242
Molecular Formula:	C₂₅H₂₂O₁₀
Molecular Weight:	482.44 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Silybum marianum (L.) Gaertn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $33.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Targets:

Caspase

In vitro:

Phytother Res. 2006 Feb;20(2):115-9.

An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.[Pubmed: 16444663]

The inhibitory effect of Silydianin, an active constituent of Silybium marianum, on the in vitro production and release of oxidative products has been examined. Polymorphonuclear neutrophils (PMNs) play a primary role in the initiation and propagation of inflammatory responses. Their apoptosis is a major mechanism associated with the resolution of inflammatory reactions. Neutrophils were assessed for caspase-3 activity, the rst step in the execution phase of apoptosis.
METHODS AND RESULTS:
When cells were cultured with 100 microM Silydianin for 24 h, caspase-3 was activated. Induction of apoptosis by Silydianin was accompanied by a decrease in luminol-enhanced chemiluminescence as well as superoxide radical (O2*-) release in freshly isolated cells and lipid peroxidation in mouse spleen microsomes. No significant effect of Silydianin on PMN hydrogen peroxide production evaluated by a flow cytometric dichlorofluorescin oxidation assay was found.
CONCLUSIONS:
Such results indicate a possible antiinflammatory activity for Silydianin, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Silydianin Description

Source:	The herbs of Silybum marianum (L.) Gaertn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Flavonoids Compound Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0728 mL	10.364 mL	20.728 mL	41.4559 mL	51.8199 mL
5 mM	0.4146 mL	2.0728 mL	4.1456 mL	8.2912 mL	10.364 mL
10 mM	0.2073 mL	1.0364 mL	2.0728 mL	4.1456 mL	5.182 mL
50 mM	0.0415 mL	0.2073 mL	0.4146 mL	0.8291 mL	1.0364 mL
100 mM	0.0207 mL	0.1036 mL	0.2073 mL	0.4146 mL	0.5182 mL

CFN95370	2,3-Dehydrosilychristin	57499-41-9	480.4	C₂₅H₂₀O₁₀
CFN95369	Isosilychristin	77182-66-2	482.4	C₂₅H₂₂O₁₀
CFN95790	Dehydroisosilychristin	N/A	480.4	C₂₅H₂₀O₁₀
CFN90260	Isosilybin	72581-71-6	482.44	C₂₅H₂₂O₁₀
CFN91070	Isosilybin A	142796-21-2	482.4	C₂₅H₂₂O₁₀
CFN91071	Isosilybin B	142796-22-3	482.4	C₂₅H₂₂O₁₀
CFN99542	Silymarin	22888-70-6	482.46	C₂₅H₂₂O₁₀
CFN95149	Silybin A	22888-70-6	482.4	C₂₅H₂₂O₁₀
CFN92916	Silybin B	142797-34-0	482.44	C₂₅H₂₂O₁₀
CFN70322	2,3-Dehydrosilybin A	25166-14-7	480.4	C₂₅H₂₀O₁₀