Swertiaperennin | CAS:22172-17-4 | Manufacturer ChemFaces

Swertiaperennin

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Description:

Reference standards.

In vitro:

Planta Med. 2003 Aug;69(8):770-2.

The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana.[Pubmed: 14531031]

Gentiana kochiana Perr. et Song. (Gentianaceae), a plant used in the traditional medicine of Tuscany (Italy) as antihypertensive remedy, exerts a vasodilator action on in vitro aortic rings that is probably linked to the blocking of the ryanodine-sensitive Ca++ channels.
METHODS AND RESULTS:
In the present study, three known xanthones were isolated from the crude methanolic extract of the roots: gentiacaulein, gentiakochianin, and Swertiaperennin. The first two showed a vasorelaxing activity in rat aortic preparations, pre-contracted by 3 microM norepinephrine (pIC50 = 5.00 +/- 0.032 for gentiacaulein, pIC50 = 4.95 +/- 0.068 for gentiakochianin), 20 mM KCl (pIC50 = 4.90 +/- 0.15 for gentiacaulein; 4.59 +/- 0.069 for gentiakochianin), or 5 mM caffeine; on the contrary, in the same conditions, Swertiaperennin did not show any vasodilator effect.
CONCLUSIONS:
In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots.

Swertiaperennin Description

Source:	The herbs of Swertia bimaculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Records of Natural Products, 2016, 10(3):287-293.

Antiplasmodial Activity and Cytotoxicity of Isolated Compound from the Stem Bark of Anthocleistaliebrechtsiana[Reference: WebLink]

METHODS AND RESULTS:
One new cerebroside derivative, namely liebrechtsianoside A (1), along with five known compounds: tetracosanoic acid (2), Swertiaperennin (3), decussatin (4), swertianin (5) and β-sitosterol glucoside (6) were isolated from the the stem bark of Anthocleista liebrechtsiana. Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in literature.
CONCLUSIONS:
Compound 1 showed the highest antiplasmodial activity against Dd2 chloroquine-resistant strain of Plasmodium falciparum.

Product Name	Swertiaperennin
Price:
CAS No.:	22172-17-4
Catalog No.:	CFN93086
Molecular Formula:	C₁₅H₁₂O₆
Molecular Weight:	288.25 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Powder
Source:	The herbs of Swertia bimaculata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Xanthones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4692 mL	17.3461 mL	34.6921 mL	69.3842 mL	86.7303 mL
5 mM	0.6938 mL	3.4692 mL	6.9384 mL	13.8768 mL	17.3461 mL
10 mM	0.3469 mL	1.7346 mL	3.4692 mL	6.9384 mL	8.673 mL
50 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.3877 mL	1.7346 mL
100 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.6938 mL	0.8673 mL

CFN98549	Methyl salicylate	119-36-8	152.15	C₈H₈O₃
CFN91611	Cannabichromenic acid	185505-15-1	358.47	C₂₂H₃₀O₄
CFN70144	Glycine	56-40-6	75.0	C₂H₅NO₂
CFN96937	Demethoxyfumitremorgin C	111768-16-2	349.43	C₂₁H₂₃N₃O₂