Structure Identification: |
J Nat Prod. 1998 Nov;61(11):1437-40. | Three novel bicyclic 3,8-secotaxane diterpenoids from the needles of the chinese yew, taxus chinensis var. mairei[Pubmed: 9834176 ] | METHODS AND RESULTS:
Three novel (1-3) and five known bicyclic 3,8-secotaxane diterpenoids were isolated from the needles of the Chinese yew, Taxus chinensis var. mairei. The structures of the new compounds were established, respectively, as (3E,7E)-2alpha,10beta, 13alpha-triacetoxy-5alpha,20-dihydroxy-3,8-secotaxa-3,7, 11-trien-9-one (1), (3E,7E)-2alpha,10beta-diacetoxy-5alpha,13alpha, 20-trihydroxy-3,8-secotaxa-3,7,11-trien-9-one (2), and (3E,8E)-7beta, 9,10beta,13alpha,20-pentaacetoxy-3,8-secotaxa-3,8,11-triene-2alpha, 5alpha-diol (2-deacetyltaxachitriene A) (3), on the basis of spectral analysis. CONCLUSIONS: The other five bicyclic taxane diterpenoids were determined as canadensene, 5-deacetylTaxachitriene B, Taxachitriene B, taxuspine U, and taxuspine X by comparison of their physical properties and spectral data with those previously reported. |
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