Tenulin | CAS:19202-92-7 | Manufacturer ChemFaces

Tenulin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg

Evodiamine

Catalog No: CFN99993
CAS No: 518-17-2
Price: $40/20mg

Catharanthine

Catalog No: CFN99765
CAS No: 2468-21-5
Price: $40/20mg

D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg

Licochalcone A

Catalog No: CFN99575
CAS No: 58749-22-7
Price: $88/20mg

Gambogenic acid

Catalog No: CFN92097
CAS No: 173932-75-7
Price: $218/20mg

Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg

Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg

Afzelin

Catalog No: CFN98757
CAS No: 482-39-3
Price: $288/20mg

Nodakenin

Catalog No: CFN90232
CAS No: 495-31-8
Price: $70/20mg

Description:

Tenulin is a potent antifeedant to the European corn borer Ostrinia nubilalis. It is also an antitumor agent, it can inhibit DNA synthesis and DNA polymerase enzymatic activity in the tumor cells.

In vivo:

J Nat Prod. 1987 Jul-Aug;50(4):690-5.

Mode of action of the sesquiterpene lactone, tenulin, from Helenium amarum against herbivorous insects.[Pubmed: 3430166]

Tenulin [1], a sesquiterpene lactone from Helenuim amarum, is a potent antifeedant to the European corn borer Ostrinia nubilalis.
METHODS AND RESULTS:
At 3 mumol/g in artificial diets, 1 reduced growth and delayed larval development of O. nubilalis and the variegated cutworm Peridroma saucia larvae. An especially pronouned carry-over effect in O. nubilis was substantial reduction in fecundity of adult moths resulting from treated larvae. The LD50 (lethal dose for 50% mortality) of 1 by injection in the migratory grasshopper Melanoplus sanguinipes was 0.88 mumol/insect. Toxicity in M. sanguinipes was antagonized by co-administration of cysteine, suggesting that the cyclopentenone group of Tenulin undergoes Michael addition of biological nucleophiles in vivo.
CONCLUSIONS:
This mechanism was partially confirmed by the finding that only Tenulin analogues capable of acting as electrophic acceptors had significant antifeedant activity.

Science. 1977 Apr 29;196(4289):533-6.

Sesquiterpene antitumor agents: inhibitors of cellular metabolism.[Pubmed: 191909]

METHODS AND RESULTS:
Helenalin and Tenulin injected into CF1 male mice bearing Ehrlich ascites tumors inhibit DNA synthesis and DNA polymerase enzymatic activity in the tumor cells. Helenalin inhibited protein synthesis. Both drugs increased the concentration of adenosine 3',5'-monophosphate, and interfered with glycolytic and mitochondrial energy processes. Cholesterol synthesis was also inhibited, resulting in lower serum cholesterol levels in tumor-bearing animals. Data obtained in vitro indicate that the cyclopentenone-bearing sesquiterpene lactone and related compounds do not alkylate puring bases of nucleic acids but rather undergo a Michael-type addition reaction with the sulfhydryl groups of reduced glutathione and l-cysteine.
CONCLUSIONS:
Thus, the inhibition of cellular enzyme activities and metabolism that has been observed with these drugs might be explained by the occurrence of a Michael-type teaction.

Tenulin Description

Source:	The herbs of Helenium amarum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tenulin
Price:
CAS No.:	19202-92-7
Catalog No.:	CFN92985
Molecular Formula:	C₁₇H₂₂O₅
Molecular Weight:	306.35 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Helenium amarum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2642 mL	16.3212 mL	32.6424 mL	65.2848 mL	81.606 mL
5 mM	0.6528 mL	3.2642 mL	6.5285 mL	13.057 mL	16.3212 mL
10 mM	0.3264 mL	1.6321 mL	3.2642 mL	6.5285 mL	8.1606 mL
50 mM	0.0653 mL	0.3264 mL	0.6528 mL	1.3057 mL	1.6321 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.6528 mL	0.8161 mL

CFN91899	Helenalin	6754-13-8	262.30	C₁₅H₁₈O₄
CFN91996	Arnicolide C	34532-67-7	334.41	C₁₉H₂₆O₅
CFN91999	Arnicolide D	34532-68-8	332.39	C₁₉H₂₄O₅
CFN91997	Microhelenin C	63569-07-3	346.42	C₂₀H₂₆O₅
CFN99694	Brevilin A	16503-32-5	346.4	C₂₀H₂₆O₅
CFN91512	Aromaticin	5945-42-6	246.3	C₁₅H₁₈O₃
CFN91510	8-epi-Helenalin	97643-91-9	262.3	C₁₅H₁₈O₄
CFN91513	Bigelovin	3668-14-2	304.3	C₁₇H₂₀O₅
CFN91511	Carpesiolin	63568-73-0	264.3	C₁₅H₂₀O₄
CFN92985	Tenulin	19202-92-7	306.35	C₁₇H₂₂O₅