Terrestrosin D | CAS:179464-23-4 | Manufacturer ChemFaces

Terrestrosin D

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Size /Price /Stock	10 mM * 1 mL in DMSO / $148.4 / In-stock
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Description:

Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D.

Targets:

VEGFR

In vitro:

Pathobiology. 2014;81(3):123-32.

Terrestrosin D, a steroidal saponin from Tribulus terrestris L., inhibits growth and angiogenesis of human prostate cancer in vitro and in vivo.[Pubmed: 24642631]

The aim of this study was to investigate whether Terrestrosin D (TED) inhibits the progression of castration-resistant prostate cancer and consider its mechanism.
METHODS AND RESULTS:
Cell cycle, mitochondrial membrane potential (ΔΨm) and apoptosis were determined by flow cytometry. Caspase-3 activity and vascular endothelial growth factor secretion were detected by a caspase-3 assay and human vascular endothelial growth factor kit, respectively. A PC-3 xenograft mouse model was used to evaluate the anticancer effect of TED in vivo. In vitro, TED strongly suppressed the growth of prostate cancer cells and endothelial cells in a dose-dependent manner. TED induced cell cycle arrest and apoptosis in PC-3 cells and human umbilical vascular endothelial cells (HUVECs). TED-induced apoptosis did not involve the caspase pathway. TED also decreased ΔΨm in PC-3 cells and HUVECs. In vivo, TED significantly suppressed tumor growth in nude mice bearing PC-3 cells, without any overt toxicity. Immunohistochemical analysis showed TED induced apoptotic cell death and inhibited angiogenesis in xenograft tumor cells.
CONCLUSIONS:
Cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of TED.

Terrestrosin D Description

Source:	The herbs of Tribulus terrestris L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 1996 Jul;42(5):1417-22.

Steroidal saponins from fruits of Tribulus terrestris.[Pubmed: 9397208]

METHODS AND RESULTS:
Further studies on the constituents of the fruits of Tribulus terrestris led to the isolation of five new steroidal saponins (terrestrosin A-E), (25R,S)-5 alpha-spirostan-3 beta-ol-3 -O-beta-D-galactopyranosyl(1-2)-beta-D- glucopyranosyl(1-4)-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-3 beta-ol-3-O-beta-D-glucopyranosyl(1-4)-[alpha-L- rhamnopyranosyl(1-2)]-beta-D-galactopyranoside, (25R,S)-5 alpha-spirostan-12-on-3 beta-ol-3-O-beta-D-galactopyranosyl (1-2)-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside, hecogenin 3-O-beta-D-galactopyranosyl)1-2)-[beta-D- xylopyranosyl(1-3)]-beta-D-glucopyranosyl(1-4)-beta-D-galactopyranoside and (25R,S)-5 alpha-spirostane-2 alpha, 3 beta-diol-3- O-beta-D-galactopyranosyl(1-2)-beta-D-glucopyranosyl(1-4)-beta-D- galactopyranoside, together with five known steroidal saponins, desgalactotigonin, F-gitonin, desglucolanatigonin, gitonin and tigogenin 3-O-beta-D- xylopyranosyl)1-2)-[beta-D-xylopyranosyl)1-3)]-beta-D-glucopyranosyl)1-4 )- [alpha-L-rhamnopyranosyl(1-2)]-beta-D-galactopyranoside.
CONCLUSIONS:
The structures of the new saponins were elucidated on the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions.

Product Name	Terrestrosin D
Price:	$168 / 10mg
CAS No.:	179464-23-4
Catalog No.:	CFN90821
Molecular Formula:	C₅₀H₈₀O₂₃
Molecular Weight:	1049.2 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Tribulus terrestris L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiangiogenic Compound Library Pro-apoptotic Compound Library Steroids Compound Library VEGFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9531 mL	4.7655 mL	9.5311 mL	19.0621 mL	23.8277 mL
5 mM	0.1906 mL	0.9531 mL	1.9062 mL	3.8124 mL	4.7655 mL
10 mM	0.0953 mL	0.4766 mL	0.9531 mL	1.9062 mL	2.3828 mL
50 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.3812 mL	0.4766 mL
100 mM	0.0095 mL	0.0477 mL	0.0953 mL	0.1906 mL	0.2383 mL

CFN99055	Mannioside A	1038922-95-0	738.9	C₃₉H₆₂O₁₃
CFN90638	Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	128502-94-3	754.9	C₃₉H₆₂O₁₄
CFN95776	25(27)-Ene-elephanoside H	1592406-40-0	752.9	C₃₉H₆₀O₁₄
CFN70458	Shatavarin IV	84633-34-1	887.1	C₄₅H₇₄O₁₇
CFN90636	14-Hydroxy sprengerinin C	1111088-89-1	871.02	C₄₄H₇₀O₁₇
CFN90614	17-Hydroxy sprengerinin C	1029017-75-1	871.02	C₄₄H₇₀O₁₇
CFN96366	Sprengerinin C	88861-91-0	855.0	C₄₄H₇₀O₁₆
CFN96364	2''-O-Acetylsprengerinin C	1220707-33-4	897.1	C₄₆H₇₂O₁₇
CFN92807	Glucopyranoside,(3beta,25R)-17-hydroxyspirost-5-en-3-yl	84914-58-9	870.5	C₄₄H₇₀O₁₇
CFN90701	Polyphyllin H	81917-50-2	871.0	C₄₄H₇₀O₁₇