Tetrahydroxymethoxychalcone | CAS:197227-39-7

Tetrahydroxymethoxychalcone

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Description:

Tetrahydroxymethoxychalcone is a phenolic and flavonoid compound. Tetrahydroxymethoxychalcone is found to enhance myoblast proliferation and differentiation. Tetrahydroxymethoxychalcone plays important roles in myogenesis and muscle regeneration.

In vitro:

Int J Mol Sci . 2021 Jan 16;22(2):876.

Isolation and Characterization of Compounds from Glycyrrhiza uralensis as Therapeutic Agents for the Muscle Disorders[Pubmed: 33467209]

Skeletal muscle is the most abundant tissue and constitutes about 40% of total body mass. Herein, we report that crude water extract (CWE) of G. uralensis enhanced myoblast proliferation and differentiation. Pretreatment of mice with the CWE of G. uralensis prior to cardiotoxin-induced muscle injury was found to enhance muscle regeneration by inducing myogenic gene expression and downregulating myostatin expression. Furthermore, this extract reduced nitrotyrosine protein levels and atrophy-related gene expression. Of the five different fractions of the CWE of G. uralensis obtained, the ethyl acetate (EtOAc) fraction more significantly enhanced myoblast proliferation and differentiation than the other fractions. Ten bioactive compounds were isolated from the EtOAc fraction and characterized by GC-MS and NMR. Of these compounds (4-hydroxybenzoic acid, liquiritigenin, (R)-(-)-vestitol, isoliquiritigenin, medicarpin, Tetrahydroxymethoxychalcone, licochalcone B, liquiritin, liquiritinapioside, and ononin), liquiritigenin, Tetrahydroxymethoxychalcone, and licochalcone B were found to enhance myoblast proliferation and differentiation, and myofiber diameters in injured muscles were wider with the liquiritigenin than the non-treated one. Computational analysis showed these compounds are non-toxic and possess good drug-likeness properties. These findings suggest that G. uralensis-extracted components might be useful therapeutic agents for the management of muscle-associated diseases.

Tetrahydroxymethoxychalcone Description

Source:	The fruits of Alpinia katsumadai
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tetrahydroxymethoxychalcone
Price:	$413 / 5mg
CAS No.:	197227-39-7
Catalog No.:	CFN91674
Molecular Formula:	C₁₆H₁₄O₆
Molecular Weight:	302.28 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Powder
Source:	The fruits of Alpinia katsumadai
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3082 mL	16.541 mL	33.0819 mL	66.1638 mL	82.7048 mL
5 mM	0.6616 mL	3.3082 mL	6.6164 mL	13.2328 mL	16.541 mL
10 mM	0.3308 mL	1.6541 mL	3.3082 mL	6.6164 mL	8.2705 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.3233 mL	1.6541 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.6616 mL	0.827 mL

CFN98776	Butein	487-52-5	272.3	C₁₅H₁₂O₅
CFN70340	Homobutein	34000-39-0	286.3	C₁₆H₁₄O₅
CFN96387	4-O-Methylbutein	13323-67-6	286.3	C₁₆H₁₄O₅
CFN91535	Calythropsin	152340-67-5	286.3	C₁₆H₁₄O₅
CFN91415	Dihydrocalythropsin	151703-05-8	288.3	C₁₆H₁₆O₅
CFN89465	3,2'-Dihydroxy-4,4'-dimethoxychalcone	2567-65-9	300.30	C₁₇H₁₆O₅
CFN91425	2',4-Dihydroxy-3,4',6'-trimethoxychalcone	1776-29-0	330.3	C₁₈H₁₈O₆
CFN90849	Okanin	484-76-4	288.3	C₁₅H₁₂O₆
CFN97522	Sappanchalcone	94344-54-4	286.3	C₁₆H₁₄O₅
CFN97767	Robtein	2679-65-4	288.25	C₁₅H₁₂O₆