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Tigloidine
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Product Name Tigloidine
Price:
CAS No.: 533-08-4
Catalog No.: CFN00231
Molecular Formula: C13H21NO2
Molecular Weight: 223.31 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The roots of Physalis peruviana (Cape Gooseberry).
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Tigloidine hydrobromide, a naturally occuring analogue of atropine, could be as a substitute for atropine in the treatment of parkinsonism.
In vivo:
Eur. J. Pharmacol., 1968, 4(3):246-53.
Pharmacology of a potential anti-Parkinson agent: tigloidine.[Pubmed: 5723419]
Pharmacological activity of Tigloidine hydrobromide, a naturally occuring analogue of atropine, was investigated in mice, rats, cats and dogs.
METHODS AND RESULTS:
In mice it markedly antagonized the effects of physostigmine and tremorine but failed to protect the animals against nicotine toxicity. On the autonomic nervous system, it had a weak parasympatholytic and gangliolytic effect compared to atropine and scopolamine. It produced hypotension in the cat which was due to both peripheral and central actions of the drug. Tigloidine did not cause any behavioral abberations in cats and dogs. However, it potentiated the amphetamine-induced behavior changes in these animals. It caused potentiation of mono and polysynaptic reflexes in the cat. In view of the reported usefulness of Tigloidine in the treatment of Parkinson's disease, its probable site and mode of action are discussed.
Tigloidine Description
Source: The roots of Physalis peruviana (Cape Gooseberry).
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4781 mL 22.3904 mL 44.7808 mL 89.5616 mL 111.952 mL
5 mM 0.8956 mL 4.4781 mL 8.9562 mL 17.9123 mL 22.3904 mL
10 mM 0.4478 mL 2.239 mL 4.4781 mL 8.9562 mL 11.1952 mL
50 mM 0.0896 mL 0.4478 mL 0.8956 mL 1.7912 mL 2.239 mL
100 mM 0.0448 mL 0.2239 mL 0.4478 mL 0.8956 mL 1.1195 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1974,13(10):2143–2144.
Biosynthesis of ticloidine in Physalis peruviana[Reference: WebLink]

METHODS AND RESULTS:
The aerial parts and roots of Physalis peruviana (Cape Gooseberry) have been shown to contain Tigloidine (3β-tigloyloxytropane) and 3α-tigloyloxytropane.
CONCLUSIONS:
The tiglic acid moiety of these alkaloids is derived from l-iSoleucine.
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Tangshenoside I

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CAS No: 117278-74-7
Price: $338/10mg
Momordicine II

Catalog No: CFN95167
CAS No: 91590-75-9
Price: $318/10mg
Silybin A

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CAS No: 22888-70-6
Price: $318/20mg
Isorhynchophylline

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CAS No: 6859-01-4
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Oxypeucedanin

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