Tigloidine | CAS:533-08-4 | Manufacturer ChemFaces

Tigloidine

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Description:

Tigloidine hydrobromide, a naturally occuring analogue of atropine, could be as a substitute for atropine in the treatment of parkinsonism.

In vivo:

Eur. J. Pharmacol., 1968, 4(3):246-53.

Pharmacology of a potential anti-Parkinson agent: tigloidine.[Pubmed: 5723419]

Pharmacological activity of Tigloidine hydrobromide, a naturally occuring analogue of atropine, was investigated in mice, rats, cats and dogs.
METHODS AND RESULTS:
In mice it markedly antagonized the effects of physostigmine and tremorine but failed to protect the animals against nicotine toxicity. On the autonomic nervous system, it had a weak parasympatholytic and gangliolytic effect compared to atropine and scopolamine. It produced hypotension in the cat which was due to both peripheral and central actions of the drug. Tigloidine did not cause any behavioral abberations in cats and dogs. However, it potentiated the amphetamine-induced behavior changes in these animals. It caused potentiation of mono and polysynaptic reflexes in the cat. In view of the reported usefulness of Tigloidine in the treatment of Parkinson's disease, its probable site and mode of action are discussed.

Tigloidine Description

Source:	The roots of Physalis peruviana (Cape Gooseberry).
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tigloidine
Price:
CAS No.:	533-08-4
Catalog No.:	CFN00231
Molecular Formula:	C₁₃H₂₁NO₂
Molecular Weight:	223.31 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The roots of Physalis peruviana (Cape Gooseberry).
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4781 mL	22.3904 mL	44.7808 mL	89.5616 mL	111.952 mL
5 mM	0.8956 mL	4.4781 mL	8.9562 mL	17.9123 mL	22.3904 mL
10 mM	0.4478 mL	2.239 mL	4.4781 mL	8.9562 mL	11.1952 mL
50 mM	0.0896 mL	0.4478 mL	0.8956 mL	1.7912 mL	2.239 mL
100 mM	0.0448 mL	0.2239 mL	0.4478 mL	0.8956 mL	1.1195 mL

CFN00212	Benzoyltropein	19145-60-9	245.32	C₁₅H₁₉NO₂
CFN00213	Cochlearine	52418-07-2	261.32	C₁₅H₁₉NO₃
CFN00216	Tropanyl 3-hydroxy-4-methoxycinnamate	86702-58-1	317.38	C₁₈H₂₃NO₄
CFN00219	Tropacocaine	537-26-8	245.32	C₁₅H₁₉NO₂
CFN00227	Atroscine	138-12-5	303.36	C₁₇H₂₁NO₄
CFN00228	Scopoline	487-27-4	155.20	C₈H₁₃NO₂
CFN00230	Tigloyltropeine	495-83-0	223.31	C₁₃H₂₁NO₂
CFN00231	Tigloidine	533-08-4	223.31	C₁₃H₂₁NO₂
CFN00232	Hyoscyamine	101-31-5	289.37	C₁₇H₂₃NO₃
CFN90713	Hyoscyamine sulfate hydrate	620-61-1	694.83	(C₁₇H₂₃NO₃)₂.H₂SO₄.H₂O