Toddaculine | CAS:4335-12-0 | Manufacturer ChemFaces

Toddaculine

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $108.3 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Korea Intitute of Science and T... (Korea)
Ateneo de Manila University (Philippines)
University of Hull (United Kingdom)
Instytut Nawozów Sztucznych w ... (Poland)

Utah State University (USA)
Universite Libre de Bruxelles (Belgium)
Worcester Polytechnic Institute (USA)
University of Otago (New Zealand)

University of Padjajaran (Indonesia)
Charles University in Prague (Czech Republic)
Universite de Lille1 (France)
More...

Package

Featured Products

More...

Caffeine

Catalog No: CFN99004
CAS No: 58-08-2
Price: $30/20mg

Caryophyllene oxide

Catalog No: CFN99239
CAS No: 1139-30-6
Price: $40/20mg

Taxiphyllin

Catalog No: CFN98070
CAS No: 21401-21-8
Price: $ /

Notoginsenoside R1

Catalog No: CFN99999
CAS No: 80418-24-2
Price: $50/20mg

Epicatechin

Catalog No: CFN98781
CAS No: 490-46-0
Price: $40/20mg

Homoplantaginin

Catalog No: CFN90344
CAS No: 17680-84-1
Price: $138/20mg

Apigenin-7-glucuronide

Catalog No: CFN98500
CAS No: 29741-09-1
Price: $80/20mg

Panaxydol

Catalog No: CFN92797
CAS No: 72800-72-7
Price: $448/20mg

Ginsenoside Rk1

Catalog No: CFN92644
CAS No: 494753-69-4
Price: $188/20mg

Kaempferitrin

Catalog No: CFN98756
CAS No: 482-38-2
Price: $100/20mg

Description:

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

Targets:

NF-kB | p38MAPK | ERK | Akt

In vitro:

PLoS One. 2015 May 18;10(5):e0127158.

Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells.[Pubmed: 25993011 ]

Osteoporosis with bone loss is widely recognized as a major health problem. Bone homeostasis is maintained by balancing bone formation and bone resorption. The imbalance caused by increased bone resorption over bone formation can lead to various bone-related diseases such as osteoporosis and rheumatoid arthritis. Osteoclasts are the principal cells responsible for bone resorption and the main targets of anti-resorptive therapies. However, excessive inhibition of osteoclast differentiation may lead to inhibition of osteoblast differentiation. Therefore, it is important to screen for new compounds capable of inhibiting bone resorption and enhancing bone formation. Toddalia asiatica (L.) Lam. has been utilized traditionally for medicinal purposes such as the treatment of rheumatism. Currently, the extract is considered to be a good source of pharmacological agents for the treatment of bone-related diseases, but the active compounds have yet to be identified.
METHODS AND RESULTS:
We investigated whether toddaculin(Toddaculine) , derived from Toddalia asiatica (L.) Lam., affects both processes by inhibiting bone resorption and enhancing bone formation. Towards this end, we used pre-osteoclastic RAW 264 cells and pre-osteoblastic MC3T3-E1 cells. We found that toddaculin(Toddaculine) not only inhibited the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but it also induced differentiation and mineralization of osteoblasts by regulating differentiation factors.
CONCLUSIONS:
Thus, toddaculin(Toddaculine) might be beneficial for the prevention and treatment of osteoporosis.

Toddaculine Description

Source:	The roots of Toddalia asiatica Lam.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Phytomedicine. 2012 Jun 15;19(8-9):737-46.

Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells.[Pubmed: 22537907]

Chemotherapeutics represent the main approach for the treatment of leukemia. However, the occurrence of adverse side effects and the complete lack of effectiveness in some cases make it necessary to develop new drugs.
METHODS AND RESULTS:
As part of our screening program to evaluate the potential chemotherapeutic effect of natural coumarins, we investigated the anti-leukemic activities of a series of six prenylated coumarins isolated from the stem bark of Toddalia asiatica (Rutaceae). Among these, 6-(3-methyl-2-butenyl)-5,7-dimethoxycoumarin (Toddaculine) displayed the most potent cytotoxic and anti-proliferative effects in U-937 cells. To determine whether these effects resulted from induction of cell death or differentiation, we further evaluated the expression of several apoptosis and maturation markers. Interestingly, while toddaculin at 250 μM was able to induce apoptosis in U-937 cells, involving decreased phosphorylation levels of ERK and Akt, 50 μM toddaculin exerted differentiating effects, inducing both the capacity of U-937 cells to reduce NBT and the expression of differentiation markers CD88 and CD11b, but no change in p-Akt or p-ERK levels.
CONCLUSIONS:
Taken together, these findings indicate that toddaculin displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents.

Product Name	Toddaculine
Price:	$318 / 10mg
CAS No.:	4335-12-0
Catalog No.:	CFN92733
Molecular Formula:	C₁₆H₁₈O₄
Molecular Weight:	274.3 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Toddalia asiatica Lam.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pro-apoptotic Compound Library Anti-osteoporosis Compound Library Antileukaemic Compound Library Coumarins Compound Library p38MAPK Inhibitor Library NF-kB Inhibitor Library ERK Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6456 mL	18.2282 mL	36.4564 mL	72.9129 mL	91.1411 mL
5 mM	0.7291 mL	3.6456 mL	7.2913 mL	14.5826 mL	18.2282 mL
10 mM	0.3646 mL	1.8228 mL	3.6456 mL	7.2913 mL	9.1141 mL
50 mM	0.0729 mL	0.3646 mL	0.7291 mL	1.4583 mL	1.8228 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	0.7291 mL	0.9114 mL

CFN92732	5-Methoxysuberenone	85011-58-1	274.3	C₁₅H₁₄O₅
CFN98985	Suberosin	581-31-7	244.3	C₁₅H₁₆O₃
CFN89248	Dehydrogeijerin	16850-91-2	258.27	C₁₅H₁₄O₄
CFN89250	Hopeyhopin	63975-56-4	274.27	C₁₅H₁₄O₅
CFN96622	Thamnosmonin	60094-90-8	276.28	C₁₅H₁₆O₅
CFN99738	Peucedanol	28095-18-3	278.30	C₁₅H₁₈O₅
CFN89411	Peucedanol 3'-O-glucoside	65891-61-4	426.41	C₂₀H₂₆O₁₀
CFN89412	Peucedanol 7-O-glucoside	65853-04-5	426.41	C₂₀H₂₆O₁₀
CFN93412	Peujaponiside	155740-16-2	558.5	C₂₅H₃₄O₁₄
CFN90999	Angelol A	19625-17-3	376.4	C₂₀H₂₄O₇