Tomentin | CAS:28449-62-9 | Manufacturer ChemFaces

Tomentin

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Description:

Tomentin has anti-inflammatory effects, it can inhibit the formation of λ-carrageenan footpad edema at 58%.

Targets:

Immunology & Inflammation related

In vivo:

Planta Med. 2014 Feb;80(2-3):209-14.

Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia.[Pubmed: 24488717 ]

Sphaeralcea angustifolia, an endangered plant species in Mexico, is employed to treat inflammatory processes and as a wound healing remedy. Scopoletin (1) was reported as one of the main bioactive compounds in this plant.
METHODS AND RESULTS:
Here, we isolated and identified compounds with anti-inflammatory properties from the suspension-cultured cells of S. angustifolia. The CH2Cl2 : CH3OH extract of the cells exhibited anti-inflammatory properties in acute inflammation models. Two compounds were isolated, 5-hydroxy-6,7-dimethoxycoumarin, named Tomentin (2), and 2-(1,8-dihydroxy-4-isopropyl-6-methyl-7-methoxy)-naphthoic acid, denominated as sphaeralcic acid (3). Their structures were determined by spectroscopic and spectrometric analyses. The anti-inflammatory effects of both compounds were also evaluated.
CONCLUSIONS:
At a dose of 45 mg/kg, compound 2 inhibited the formation of λ-carrageenan footpad edema at 58 %, and compound 3 at 66 %. Local application of compound 2 (225 mM per ear) or 3 (174 mM per ear) inhibited the phorbol ester-induced auricular edema formation by 57 % or 86 %, respectively. The effect of compound 3 was dose-dependent and the ED50 was 93 mM.

Tomentin Description

Source:	The barks of Jatropha curcas
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tomentin
Price:
CAS No.:	28449-62-9
Catalog No.:	CFN98347
Molecular Formula:	C₁₁H₁₀O₅
Molecular Weight:	222.2 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The barks of Jatropha curcas
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Coumarins Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5005 mL	22.5023 mL	45.0045 mL	90.009 mL	112.5113 mL
5 mM	0.9001 mL	4.5005 mL	9.0009 mL	18.0018 mL	22.5023 mL
10 mM	0.45 mL	2.2502 mL	4.5005 mL	9.0009 mL	11.2511 mL
50 mM	0.09 mL	0.45 mL	0.9001 mL	1.8002 mL	2.2502 mL
100 mM	0.045 mL	0.225 mL	0.45 mL	0.9001 mL	1.1251 mL

CFN70467	8-Acetyl-7-methoxycoumarin	89019-07-8	218.2	C₁₂H₁₀O₄
CFN97036	5,7,8-Trimethoxycoumarin	60796-65-8	236.2	C₁₂H₁₂O₅
CFN97547	Artanin	96917-26-9	290.3	C₁₆H₁₈O₅
CFN91660	Neoartanin	104196-69-2	290.31	C₁₆H₁₈O₅
CFN99344	8-Geranyloxy-5,7-dimethoxycoumarin	1228175-65-2	358.4	C₂₁H₂₆O₅
CFN92736	Arteminin	466639-11-2	222.2	C₁₁H₁₀O₅
CFN98768	Fraxinol	486-28-2	222.2	C₁₁H₁₀O₅
CFN70362	Umckalin	43053-62-9	222.2	C₁₁H₁₀O₅
CFN98347	Tomentin	28449-62-9	222.2	C₁₁H₁₀O₅
CFN89309	5,6,7-Trimethoxycoumarin	55085-47-7	236.22	C₁₂H₁₂O₅