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Torilolone
Torilolone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Torilolone
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CAS No.: 13018-09-2
Catalog No.: CFN96368
Molecular Formula: C15H24O3
Molecular Weight: 252.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Cryst.
Source: The herbs of Cnidium monnieri.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 +/- 3.4 microM.
In vitro:
Planta Med. 2002 Aug;68(8):748-9.
Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells.[Pubmed: 12221602 ]

METHODS AND RESULTS:
Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and Torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively.
CONCLUSIONS:
Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.
Torilolone Description
Source: The herbs of Cnidium monnieri.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.962 mL 19.8098 mL 39.6197 mL 79.2393 mL 99.0491 mL
5 mM 0.7924 mL 3.962 mL 7.9239 mL 15.8479 mL 19.8098 mL
10 mM 0.3962 mL 1.981 mL 3.962 mL 7.9239 mL 9.9049 mL
50 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.5848 mL 1.981 mL
100 mM 0.0396 mL 0.1981 mL 0.3962 mL 0.7924 mL 0.9905 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN92614Curcumenol19431-84-6234.3C15H22O2
CFN92618Isocurcumenol24063-71-6234.3C15H22O2
CFN99187Curcumol4871-97-0236.35C15H24O2
CFN909474beta,12-dihydroxyguaian-6,10-diene461644-90-6236.34C15H24O2
CFN97477Chrysothol911714-91-5238.4 C15H26O2
CFN97446Alismol87827-55-2220.4 C15H24O
CFN99775Alismoxide87701-68-6238.37C15H26O2
CFN96326Guaiol489-86-1222.4C15H26O
CFN99634Teuclatriol152110-17-3256.4 C15H28O3
CFN98560Atractyloside A126054-77-1448.5C21H36O10
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