Tricine | CAS:5704-04-1 | Manufacturer ChemFaces

Tricine

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Tricine can clearly visualize tumors, may as melanoma imaging agents. Using the combination of tricine and a phosphine ligand, HYNIC-derivatized peptides or other small molecules can be labeled with 99mTc in high specific activity and with high stability for potential use as radiopharmaceuticals.

In vitro:

J. Immunol. Methods,1990 Jan 24;1 26(1):109-17.

Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis.[Pubmed: 2106001]

METHODS AND RESULTS:
We utilized the recently described Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (TSDS-PAGE) system to study the lipooligosaccharides (LOS) and lipopolysaccharides (LPS) of gram negative bacteria. TSDS-PAGE resulted in a high degree of resolution of LOS and LPS in the 'mini-gel' format. TSDS-PAGE resulted in the LOS and LPS migrating as a function of their Mr during electrophoresis and allowed estimation of Mr from a protein standard. Several species of LOS were analyzed.
CONCLUSIONS:
The newly described procedure allowed a more rapid and accurate analysis of LOS and the core region of LPS.

In vivo:

Anticancer Agents Med Chem. 2014;15(1):122-30.

Evaluation of tricine and EDDA as Co-ligands for 99mTc-labeled HYNIC-MSH analogs for melanoma imaging.[Pubmed: 25175799 ]

Several radiolabeled alpha-melanocyte stimulating hormone (α-MSH) analogs have been studied for their abilities to target melanoma tumor cells through specific recognition and binding to the melanocortin receptor 1 (MCR1).
METHODS AND RESULTS:
In this work, a lactam bridgecyclized α-MSH analog was labeled with (99m) via the hydrazinonicotinamide (HYNIC) chelator and characterized for its melanoma tumor targeting properties. The bifunctional chelating agent HYNIC-Boc was attached to the N-terminus of the MSH peptide followed by the lactam cyclization, resulting in the HYNIC-cyc-MSH analog. The lactam cyclized peptide displayed high affinity and specificity for MC1-receptors present on B16/F1 melanoma tumor cells, exhibiting an IC50 of 6.48 nM. HYNIC-cyc-MSH was radiolabeled with (99m)Tc using two common co-ligands, Tricine and EDDA. In vitro, the radiochemical stability, cell binding and efflux properties were similar between the peptides radiolabeled with Tricine and EDDA as co-ligands. In vivo, biodistribution studies (n=4) demonstrated that (99m)Tc- HYNIC-cyc-MSH/Tricine had superior tumor to muscle and tumor to blood ratios than (99m)Tc-HYNIC-cyc-MSH/EDDA at early time points.
CONCLUSIONS:
Planar gamma imaging of melanoma bearing mice showed that 99mTc-HYNIC-cyc-MSH/Tricine was able to clearly visualize tumors, underscoring the potential utility of (99m)Tc labeled lactam cyclized MSH molecules as melanoma imaging agents.

Tricine Description

Source:	The roots of Beta vulgaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Tricine
Price:	$40 / 20mg
CAS No.:	5704-04-1
Catalog No.:	CFN98511
Molecular Formula:	C₆H₁₃NO₅
Molecular Weight:	179.17 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	White powder
Source:	The roots of Beta vulgaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Markers Compound Library Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.5813 mL	27.9065 mL	55.8129 mL	111.6258 mL	139.5323 mL
5 mM	1.1163 mL	5.5813 mL	11.1626 mL	22.3252 mL	27.9065 mL
10 mM	0.5581 mL	2.7906 mL	5.5813 mL	11.1626 mL	13.9532 mL
50 mM	0.1116 mL	0.5581 mL	1.1163 mL	2.2325 mL	2.7906 mL
100 mM	0.0558 mL	0.2791 mL	0.5581 mL	1.1163 mL	1.3953 mL

CFN95096	1,3,6-Trihydroxy-2-methylanthraquinone 3-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside	87686-88-2	578.5	C₂₇H₃₀O₁₄
CFN91589	Crosstide	171783-05-4	1164.2	C₄₈H₇₇N₁₇O₁₇
CFN98495	6-Hydroxystigmasta-4,22-dien-3-one	36450-01-8	426.7	C₂₉H₄₆O₂
CFN97303	Khellin	82-02-0	260.2	C₁₄H₁₂O₅