Science | Nature | Cell | View More
Natural Products
Uvedalin
Uvedalin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Uvedalin
Price:
CAS No.: 24694-79-9
Catalog No.: CFN97776
Molecular Formula: C23H28O9
Molecular Weight: 448.47 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Smallanthus sonchifolius
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Tokyo Woman's Christian University (Japan)
  • University of Hull (United Kingdom)
  • Helmholtz Zentrum München (Germany)
  • Complutense University of Madrid (Spain)
  • Sant Gadge Baba Amravati Univer... (India)
  • Seoul National University (Korea)
  • Indian Institute of Science (India)
  • Anna University (India)
  • University of Amsterdam (Netherlands)
  • Monash University (Australia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
Package
Featured Products
Rhein

Catalog No: CFN99157
CAS No: 478-43-3
Price: $40/20mg
Adenine

Catalog No: CFN89041
CAS No: 73-24-5
Price: $30/20mg
Gypenoside XIII

Catalog No: CFN95239
CAS No: 80325-22-0
Price: $288/10mg
Tetrahydropalmatine

Catalog No: CFN99553
CAS No: 2934-97-6
Price: $30/20mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Berbamine

Catalog No: CFN98727
CAS No: 478-61-5
Price: $50/20mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Gypenoside L

Catalog No: CFN91854
CAS No: 94987-09-4
Price: $268/5mg
Curculigoside

Catalog No: CFN97419
CAS No: 85643-19-2
Price: $70/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines.
In vitro:
Zygote. 2015 Jun;23(3):406-11.
Effect of different types of sesquiterpene lactones on the maturation of Rhinella arenarum oocytes.[Pubmed: 24522008]
The sesquiterpene lactones (STLs) are a large class of plant secondary metabolites that are generally found in the Asteraceae family and that have high diversity with respect to chemical structure as well as biological activity. STLs have been classified into different groups, such as guaianolides, germacranolides, and melampolides etc., based on their carboxylic skeleton. In amphibians, fully grown ovarian oocytes are arrested at the beginning of meiosis I. Under the stimulus of progesterone, this meiotic arrest is released and meiosis progresses to metaphase II, a process known as oocyte maturation. The purpose of this work was to determine whether sesquiterpene lactones from the germacranolide and melampolide groups act as inhibitor agents on the meiosis of amphibian oocytes in vitro.
METHODS AND RESULTS:
Results for germacranolides indicated that the addition of deoxyelephantopins caused a high degree of inhibition and that minimolide showed a moderate inhibitory effect, whereas glaucolide A was inactive. Furthermore, the addition of melampolides (Uvedalin, enhydrin, polymatin A and polymatin B) showed inhibitory effects. For enhydrin and Uvedalin, inhibitory effects were observed at the higher concentrations assayed. The results of this study suggest that the inhibitory activity of the tested sesquiterpene lactones on the meiosis of Rhinella arenarum oocytes is not dependent on the group to which they belong, i.e. not on the carboxylic skeleton, but probably due to the arrangement and type of function groups present in the molecules.
CONCLUSIONS:
All assayed lactones in the germacranolide group showed low toxicity. In contrast, important differences in toxicity were observed for lactones from the melampolide group: enhydrin and Uvedalin showed low toxicity, but polymatin A and B were highly toxic.
Evid Based Complement Alternat Med. 2013;2013:627898.
Trypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation.[Pubmed: 23840260]

METHODS AND RESULTS:
In order to find novel plant-derived biologically active compounds against Trypanosoma cruzi, we isolated, from the organic extract of Smallanthus sonchifolius, the sesquiterpene lactones enhydrin (1), Uvedalin (2), and polymatin B (3) by bioassay-guided fractionation technique. These compounds showed a significant trypanocidal activity against the epimastigote forms of the parasite with IC50 values of 0.84  μ M (1), 1.09  μ M (2), and 4.90  μ M (3). After a 24 h treatment with 10  μ g/mL of enhydrin or Uvedalin, parasites were not able to recover their replication rate. Compounds 1 and 2 showed IC50 values of 33.4  μ M and 25.0  μ M against T. cruzi trypomastigotes, while polymatin B was not active. When the three compounds were tested against the intracellular forms of T. cruzi, they were able to inhibit the amastigote replication with IC50 of 5.17  μ M, 3.34  μ M, and 9.02  μ M for 1, 2, and 3, respectively. The cytotoxicity of the compounds was evaluated in Vero cells obtaining CC50 values of 46.5  μ M (1), 46.8  μ M (2), and 147.3  μ M (3) and the selectivity index calculated.
CONCLUSIONS:
According to these results, enhydrin and Uvedalin might have potentials as agents against Chagas disease and could serve as lead molecules to develop new drugs.
Uvedalin Description
Source: The herbs of Smallanthus sonchifolius
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
13(S)-Hydroxyoctadeca-9(Z),11(E)-d...

Catalog No: CFN95307
CAS No: 18104-45-5
Price: $318/10mg
New compound 20

Catalog No: CFN95545
CAS No: N/A
Price: $413/5mg
Toddalolactone 3'-O-methyl ether (...

Catalog No: CFN95372
CAS No: 143614-35-1
Price: $318/10mg
Schisphenlignan I

Catalog No: CFN95586
CAS No: 1542234-14-9
Price: $318/5mg
(3,4-Dihydroxyphenyl)methyl 3-(bet...

Catalog No: CFN95531
CAS No: 877461-90-0
Price: $318/10mg
Pilosidine

Catalog No: CFN95110
CAS No: 229971-57-7
Price: $413/5mg
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $298/10mg
11-Oxomogroside IIA2

Catalog No: CFN95305
CAS No: 2170761-37-0
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2298 mL 11.149 mL 22.298 mL 44.5961 mL 55.7451 mL
5 mM 0.446 mL 2.2298 mL 4.4596 mL 8.9192 mL 11.149 mL
10 mM 0.223 mL 1.1149 mL 2.2298 mL 4.4596 mL 5.5745 mL
50 mM 0.0446 mL 0.223 mL 0.446 mL 0.8919 mL 1.1149 mL
100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.446 mL 0.5575 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Agric Food Chem. 2015 Dec 23;63(50):10856-61.
New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines.[Pubmed: 26576855 ]
Uvedafolin, 1, a new sesquiterpene lactone dimer, was isolated from the leaves of Smallanthus sonchifolius with five related compounds, 2-6, and their cytotoxicity was assessed against three tumor cell lines (HeLa, HL-60, B16-F10 melanoma).
METHODS AND RESULTS:
The stereostructure of 1 was newly elucidated by ESI-TOF-MS, 1D/2D NMR, and single-crystal X-ray diffraction. Dimers 1 and 2 had the most effective IC50 values, 0.2-1.9 μM, against the three tumor cell lines when compared with monomers 3-6 (IC50 values 0.7-9.9 μM) and etoposide (IC50 values 0.8-114 μM). The ester linkages of two sets of monomers, Uvedalin, 5, and sonchifolin, 6, for 1, and enhydrin, 4, and sonchifolin, 6, for 2, as well as the acetyl group at the C-9 position, were essential for the high cytotoxicity. Dimers 1 and 2 would have potential as anticancer agents.
Rhein

Catalog No: CFN99157
CAS No: 478-43-3
Price: $40/20mg
Adenine

Catalog No: CFN89041
CAS No: 73-24-5
Price: $30/20mg
Gypenoside XIII

Catalog No: CFN95239
CAS No: 80325-22-0
Price: $288/10mg
Tetrahydropalmatine

Catalog No: CFN99553
CAS No: 2934-97-6
Price: $30/20mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Berbamine

Catalog No: CFN98727
CAS No: 478-61-5
Price: $50/20mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Gypenoside L

Catalog No: CFN91854
CAS No: 94987-09-4
Price: $268/5mg
Curculigoside

Catalog No: CFN97419
CAS No: 85643-19-2
Price: $70/20mg
Tags: buy Uvedalin | Uvedalin supplier | purchase Uvedalin | Uvedalin cost | Uvedalin manufacturer | order Uvedalin | Uvedalin distributor