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Veratramine
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Product Name Veratramine
Price: $40 / 20mg
CAS No.: 60-70-8
Catalog No.: CFN90929
Molecular Formula: C27H39NO2
Molecular Weight: 409.6 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Veratrum nigrum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $12.7 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Veratramine exhibits cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Veratramine shows hypotensive effect, the effect is directly positively correlated with the dosage.
In vitro:
Phytother Res. 2008 Aug;22(8):1093-6.
Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.[Pubmed: 18570211 ]

METHODS AND RESULTS:
The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (Veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249.
CONCLUSIONS:
Among these samples, CHCl(3) fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.
In vivo:
Pharmazie. 2008 Aug;63(8):606-10.
Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats.[Pubmed: 18771011]

METHODS AND RESULTS:
Total alkaloids (VTA) and Veratramine of Veratrum nigrum L. were tested for hypotensive effect using spontaneously hypertensive rats (SHR). Acute toxicities were also evaluated. There was a dose-dependent reduction in blood pressure and heart rate after a single ingestion (1.0 to 4.0 mg/kg, intragastric administration) of VTA. A single oral ingestion (0.56 to 2.24 mg/kg) of Veratramine, the major component of VTA, dose-dependently decreased blood pressure and heart rate, suggesting that Veratramine was involved in the hypotensive effect of VTA in SHR.
CONCLUSIONS:
The hypotensive effects of VTA and Veratramine are directly positively correlated with the dosage. Side effects were not obvious.
AAPS J. 2016 Mar;18(2):432-44.
Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.[Pubmed: 26791530]
Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. Our previous study indicated that Veratramine had severe toxicity toward male rats.
METHODS AND RESULTS:
In order to elucidate the underling mechanism, in vivo pharmacokinetic experiments and in vitro mechanistic studies have been conducted. Veratramine was administrated to male and female rats intravenously via the jugular vein at a dose of 50 μg/kg or orally via gavage at 20 mg/kg. As a result, significant pharmacokinetic differences were observed between male and female rats after oral administration with much lower concentrations of Veratramine and 7-hydroxyl-Veratramine and higher concentrations of Veratramine-3-O-sulfate found in the plasma and urine of female rats. The absolute bioavailability of Veratramine was 0.9% in female rats and 22.5% in male rats. Further experiments of Veratramine on Caco-2 cell monolayer model and in vitro incubation with GI content or rat intestinal subcellular fractions demonstrated that its efficient passive diffusion mediated absorption with minimal intestinal metabolism, suggesting no gender-related difference during its absorption process. When Veratramine was incubated with male or female rat liver microsomes/cytosols, significant male-predominant formation of 7-hydroxyl-Veratramine and female-predominant formation of Veratramine-3-O-sulfate were observed.
CONCLUSIONS:
In conclusion, the significant gender-dependent hepatic metabolism of Veratramine could be the major contributor to its gender-dependent pharmacokinetics.
Veratramine Description
Source: The herbs of Veratrum nigrum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4414 mL 12.207 mL 24.4141 mL 48.8281 mL 61.0352 mL
5 mM 0.4883 mL 2.4414 mL 4.8828 mL 9.7656 mL 12.207 mL
10 mM 0.2441 mL 1.2207 mL 2.4414 mL 4.8828 mL 6.1035 mL
50 mM 0.0488 mL 0.2441 mL 0.4883 mL 0.9766 mL 1.2207 mL
100 mM 0.0244 mL 0.1221 mL 0.2441 mL 0.4883 mL 0.6104 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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Supinine

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