Vulpic acid | CAS:521-52-8 | Manufacturer ChemFaces

Vulpic acid

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $109.4 / In-stock
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Description:

Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents, it can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity.

Targets:

Fatty Acid Synthase

In vitro:

J Nat Prod. 2013 Jun 28;76(6):1064-70.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.[Pubmed: 23806111]

Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria.
METHODS AND RESULTS:
In this study, four lichen metabolites, evernic acid (1), Vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis).
CONCLUSIONS:
Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.

Vulpic acid Description

Source:	From lichen metabolites.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vulpic acid
Price:	$198 / 5mg
CAS No.:	521-52-8
Catalog No.:	CFN94427
Molecular Formula:	C₁₉H₁₄O₅
Molecular Weight:	322.32 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	From lichen metabolites.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antibacterial Compound Library Antimalaric Compound Library Miscellaneous Compound Library Fatty Acid Synthase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1025 mL	15.5125 mL	31.0251 mL	62.0501 mL	77.5627 mL
5 mM	0.6205 mL	3.1025 mL	6.205 mL	12.41 mL	15.5125 mL
10 mM	0.3103 mL	1.5513 mL	3.1025 mL	6.205 mL	7.7563 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL	1.241 mL	1.5513 mL
100 mM	0.031 mL	0.1551 mL	0.3103 mL	0.6205 mL	0.7756 mL

CFN95673	(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone	1932291-56-9	190.2	C₁₂H₁₄O₂
CFN95694	Pyrolone B	1014978-30-3	206.2	C₁₂H₁₄O₃
CFN97769	4-(cis)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone	263368-92-9	250.25	C₁₃H₁₄O₅
CFN97770	4-(trans)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone	263368-91-8	250.25	C₁₃H₁₄O₅
CFN93653	Brevifolincarboxylic acid	18490-95-4	292.2	C₁₃H₈O₈
CFN94427	Vulpic acid	521-52-8	322.32	C₁₉H₁₄O₅