Science | Nature | Cell | View More
Natural Products
Vulpic acid
Vulpic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vulpic acid
Price: $198 / 5mg
CAS No.: 521-52-8
Catalog No.: CFN94427
Molecular Formula: C19H14O5
Molecular Weight: 322.32 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: From lichen metabolites.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $109.4 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Madras (India)
  • University of Leipzig (Germany)
  • Massachusetts General Hospital (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Shanghai Institute of Biochemis... (China)
  • University of Otago (New Zealand)
  • MTT Agrifood Research Finland (Finland)
  • University of Hawaii Cancer Center (USA)
  • University of Ioannina (Greece)
  • Wroclaw Medical University (Poland)
  • University of Minnesota (USA)
  • More...
Package
Featured Products
Deapi-platycodin D

Catalog No: CFN90472
CAS No: 78763-58-3
Price: $188/10mg
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Demethylsuberosin

Catalog No: CFN96241
CAS No: 21422-04-8
Price: $188/20mg
Tangshenoside I

Catalog No: CFN95108
CAS No: 117278-74-7
Price: $338/10mg
Luteolin

Catalog No: CFN98784
CAS No: 491-70-3
Price: $40/20mg
Tectoridin

Catalog No: CFN99921
CAS No: 611-40-5
Price: $50/20mg
Curculigoside

Catalog No: CFN97419
CAS No: 85643-19-2
Price: $70/20mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Poricoic acid A(F)

Catalog No: CFN92838
CAS No: 137551-38-3
Price: $218/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents, it can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity.
Targets: Fatty Acid Synthase
In vitro:
J Nat Prod. 2013 Jun 28;76(6):1064-70.
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.[Pubmed: 23806111]
Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria.
METHODS AND RESULTS:
In this study, four lichen metabolites, evernic acid (1), Vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis).
CONCLUSIONS:
Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.
Vulpic acid Description
Source: From lichen metabolites.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New Compound 1

Catalog No: CFN95152
CAS No: N/A
Price: $318/5mg
Methyl ganoderate A

Catalog No: CFN95550
CAS No: 105742-78-7
Price: $413/5mg
1-Methoxycarbonyl-beta-carboline-N...

Catalog No: CFN95023
CAS No: 74690-74-7
Price: $318/5mg
Lariciresinol 4'-O-glucoside

Catalog No: CFN95400
CAS No: 107110-16-7
Price: $318/5mg
Magnaldehyde B

Catalog No: CFN95075
CAS No: 92829-72-6
Price: $318/5mg
Clemomandshuricoside B

Catalog No: CFN95302
CAS No: 905294-48-6
Price: $318/10mg
cis-Mulberroside A

Catalog No: CFN95006
CAS No: 166734-06-1
Price: $368/10mg
Diosniposide B

Catalog No: CFN95333
CAS No: N/A
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1025 mL 15.5125 mL 31.0251 mL 62.0501 mL 77.5627 mL
5 mM 0.6205 mL 3.1025 mL 6.205 mL 12.41 mL 15.5125 mL
10 mM 0.3103 mL 1.5513 mL 3.1025 mL 6.205 mL 7.7563 mL
50 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.241 mL 1.5513 mL
100 mM 0.031 mL 0.1551 mL 0.3103 mL 0.6205 mL 0.7756 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Deapi-platycodin D

Catalog No: CFN90472
CAS No: 78763-58-3
Price: $188/10mg
Calycosin

Catalog No: CFN99140
CAS No: 20575-57-9
Price: $80/20mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Demethylsuberosin

Catalog No: CFN96241
CAS No: 21422-04-8
Price: $188/20mg
Tangshenoside I

Catalog No: CFN95108
CAS No: 117278-74-7
Price: $338/10mg
Luteolin

Catalog No: CFN98784
CAS No: 491-70-3
Price: $40/20mg
Tectoridin

Catalog No: CFN99921
CAS No: 611-40-5
Price: $50/20mg
Curculigoside

Catalog No: CFN97419
CAS No: 85643-19-2
Price: $70/20mg
Silybin B

Catalog No: CFN92916
CAS No: 142797-34-0
Price: $368/20mg
Poricoic acid A(F)

Catalog No: CFN92838
CAS No: 137551-38-3
Price: $218/20mg
Tags: buy Vulpic acid | Vulpic acid supplier | purchase Vulpic acid | Vulpic acid cost | Vulpic acid manufacturer | order Vulpic acid | Vulpic acid distributor