Wilforlide A | CAS:84104-71-2 | Manufacturer ChemFaces

Wilforlide A

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Product Name	Wilforlide A
Price:	$80 / 20mg
CAS No.:	84104-71-2
Catalog No.:	CFN97335
Molecular Formula:	C₃₀H₄₆O₃
Molecular Weight:	454.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Tripterygium wilfordii Hook.f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $25.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Wilforlide A is a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. Wilforlide A has obvious anti-inflammatory effects.

Targets:

Immunology & Inflammation related

In vitro:

Fitoterapia. 2010 Dec;81(8):1109-12.

Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.[Pubmed: 20621167]

Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T(1)) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. The pharmacologic actions of T(1) remain to be unidentified.
METHODS AND RESULTS:
In this paper, we studied the anti-inflammatory and immune suppressive effect of T(1), and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T(1) has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured.
CONCLUSIONS:
The results show that T(1) has no significant immune suppressive activity, and there has a significant difference with TP and TG. Therefore, we think the content of TP also should be controlled as a supplement standard in order to ensure safe and effective medication.

Wilforlide A Description

Source:	The herbs of Tripterygium wilfordii Hook.f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Quality control indexes Compound Library Triterpenoids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1993 mL	10.9963 mL	21.9925 mL	43.985 mL	54.9813 mL
5 mM	0.4399 mL	2.1993 mL	4.3985 mL	8.797 mL	10.9963 mL
10 mM	0.2199 mL	1.0996 mL	2.1993 mL	4.3985 mL	5.4981 mL
50 mM	0.044 mL	0.2199 mL	0.4399 mL	0.8797 mL	1.0996 mL
100 mM	0.022 mL	0.11 mL	0.2199 mL	0.4399 mL	0.5498 mL

CFN97335	Wilforlide A	84104-71-2	454.7	C₃₀H₄₆O₃
CFN97336	Wilforlide A acetate	84104-80-3	496.7	C₃₂H₄₈O₄
CFN96834	Polpunonic acid	33600-93-0	456.71	C₃₀H₄₈O₃
CFN96837	Salaspermic acid	71247-78-4	472.71	C₃₀H₄₈O₄
CFN89150	Canophyllal	14440-40-5	440.71	C₃₀H₄₈O₂
CFN98260	Bryonolic acid	24480-45-3	456.7	C₃₀H₄₈O₃
CFN99152	Glycyrrhetinic acid	471-53-4	470.64	C₃₀H₄₆O₄
CFN97747	28-Hydroxy-3-oxoolean-12-en-29-oic acid	381691-22-1	470.69	C₃₀H₄₆O₄
CFN99487	22-Hydroxy-3-oxoolean-12-en-29-oic acid	144629-84-5	470.7	C₃₀H₄₆O₄
CFN97288	3,22-Dihydroxyolean-12-en-29-oic acid	808769-54-2	472.7	C₃₀H₄₈O₄