Science | Nature | Cell | View More
Natural Products
Withanoside V
Withanoside V
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Withanoside V
Price:
CAS No.: 256520-90-8
Catalog No.: CFN70323
Molecular Formula: C40H62O14
Molecular Weight: 766.9 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Withania somnifera
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Amsterdam (Netherlands)
  • Cornell University (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • Harvard University (USA)
  • Monash University Malaysia (Malaysia)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • Deutsches Krebsforschungszentrum (Germany)
  • Mahatma Gandhi University (India)
  • Martin Luther University of Hal... (Germany)
  • Griffith University (Australia)
  • Donald Danforth Plant Science C... (USA)
  • More...
Package
Featured Products
Beta-boswellic acid

Catalog No: CFN90221
CAS No: 631-69-6
Price: $218/20mg
Isobavachin

Catalog No: CFN98400
CAS No: 31524-62-6
Price: $138/20mg
Eriodictyol

Catalog No: CFN99719
CAS No: 552-58-9
Price: $128/20mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
L-Glutamic acid

Catalog No: CFN93108
CAS No: 56-86-0
Price: $30/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Cyanidin Chloride

Catalog No: CFN99741
CAS No: 528-58-5
Price: $198/20mg
Corylin

Catalog No: CFN98902
CAS No: 53947-92-5
Price: $90/20mg
Linarin

Catalog No: CFN98738
CAS No: 480-36-4
Price: $40/20mg
(+)-Pteryxin

Catalog No: CFN92559
CAS No: 13161-75-6
Price: $188/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
Journal of Advanced Pharmaceutical Technology & Research, 01 Oct 2015, 6(4):159-164.
Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system.[Reference: WebLink]
Withania somnifera (L.) Dunal, shows several pharmacological properties which are attributed mainly to the withanolides present in the root. The efficacy of medicinally active withanolides constituents depends on the absorption and transportation through the intestinal epithelium. We examined these characteristics by employing the Sino-Veda Madin-Darby canine kidney cells culture system, which under in vitro condition shows the absorption characteristics similar to the human intestinal epithelium. Thus, the aim of the present investigation was to assess the bioavailability of individual withanolides.
METHODS AND RESULTS:
Withanolides were diluted in Hank's buffered saline at a concentration of 2 μg/ml were tested for permeability studies carried out for 1 h duration. Permeability was measured in terms of efflux pump (P eff) in cm/s. P eff values of withanolide A (WN A), withanone (WNN), 1,2-deoxywithastramonolide (1,2 DWM), withanolide B (WN B), withanoside IV-Withanoside V (WS IV-V), and withaferin A were 4.05 × 10(-5), 2.06 × 10(-5), 1.97 × 10(-5), 1.80 × 10(-5), 3.19 × 10(-6), 3.03 × 10(-6) and 3.30 × 10(-7) respectively. In conclusion, the nonpolar and low molecular weight compounds (WN A, WNN, 1,2 DWM, and WN B) were highly permeable. As against this, the glycosylated and polar WS IV and WS V showed low permeability.
CONCLUSIONS:
Surprisingly and paradoxically, the highly biologically active withaferin A was completely impermeable, suggesting that further studies possibly using human epithelial colorectal adenocarcinoma (Caco-2) cells may be needed to delineate the absorption characteristics of withanolides, especially withaferin A.
Withanoside V Description
Source: The herbs of Withania somnifera
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Apigenin 7-O-(6''-O-malonylglucosi...

Catalog No: CFN95163
CAS No: 86546-87-4
Price: $318/5mg
1,3,6-Trihydroxy-2-methylanthraqui...

Catalog No: CFN95095
CAS No: 87686-87-1
Price: $218/10mg
Methyl ganoderate E

Catalog No: CFN95582
CAS No: 98718-43-5
Price: $413/5mg
Complanatoside C

Catalog No: CFN95144
CAS No: N/A
Price: $318/5mg
2-Phenylethyl-beta-glucopyranoside

Catalog No: CFN95429
CAS No: 18997-54-1
Price: $318/10mg
Yuanhuanin

Catalog No: CFN95127
CAS No: 83133-14-6
Price: $318/5mg
Murracarpin

Catalog No: CFN95409
CAS No: 120786-76-7
Price: $413/5mg
New compound 22

Catalog No: CFN95570
CAS No: N/A
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.304 mL 6.5198 mL 13.0395 mL 26.079 mL 32.5988 mL
5 mM 0.2608 mL 1.304 mL 2.6079 mL 5.2158 mL 6.5198 mL
10 mM 0.1304 mL 0.652 mL 1.304 mL 2.6079 mL 3.2599 mL
50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.5216 mL 0.652 mL
100 mM 0.013 mL 0.0652 mL 0.1304 mL 0.2608 mL 0.326 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorganic & medicinal chemistry, 2001, 9(6):1499-1507.
Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera Dunal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum.[Reference: WebLink]

METHODS AND RESULTS:
Seven new withanolide glycosides called withanoside I, withanoside II, withanoside III, withanoside IV, Withanoside V, Withanoside VI, and Withanoside VII were isolated from an Indian natural medicine, Ashwagandha, the roots of Indian Withania somnifera Dunal. (Solanaceae), together with four known compounds, withaferin A, 5α,20αF(R)-dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide, physagulin D, and coagulin Q. The structures of withanoside I, withanoside II, withanoside III, withanoside IV, Withanoside V, Withanoside VI, and Withanoside VII were determined based on chemical and physicochemical evidence.
CONCLUSIONS:
Principal constituents, Withanoside VI (10 and 30 μM) and withaferin A (10 μM), attenuated the tachyphylaxis to clonidine on electrically stimulated guinea-pig ileum in vitro.
Beta-boswellic acid

Catalog No: CFN90221
CAS No: 631-69-6
Price: $218/20mg
Isobavachin

Catalog No: CFN98400
CAS No: 31524-62-6
Price: $138/20mg
Eriodictyol

Catalog No: CFN99719
CAS No: 552-58-9
Price: $128/20mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
L-Glutamic acid

Catalog No: CFN93108
CAS No: 56-86-0
Price: $30/20mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Cyanidin Chloride

Catalog No: CFN99741
CAS No: 528-58-5
Price: $198/20mg
Corylin

Catalog No: CFN98902
CAS No: 53947-92-5
Price: $90/20mg
Linarin

Catalog No: CFN98738
CAS No: 480-36-4
Price: $40/20mg
(+)-Pteryxin

Catalog No: CFN92559
CAS No: 13161-75-6
Price: $188/20mg
Tags: buy Withanoside V | Withanoside V supplier | purchase Withanoside V | Withanoside V cost | Withanoside V manufacturer | order Withanoside V | Withanoside V distributor