alpha-L-Rhamnose | CAS:3615-41-6 | Manufacturer ChemFaces

alpha-L-Rhamnose

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg

Cosmosiin

Catalog No: CFN98981
CAS No: 578-74-5
Price: $80/20mg

Magnolignan A

Catalog No: CFN96188
CAS No: 93673-81-5
Price: $318/10mg

(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg

3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg

Gartanin

Catalog No: CFN98428
CAS No: 33390-42-0
Price: $318/5mg

Physalin L

Catalog No: CFN90166
CAS No: 113146-74-0
Price: $288/5mg

Baicalein

Catalog No: CFN98783
CAS No: 491-67-8
Price: $40/20mg

Ligustilide

Catalog No: CFN99932
CAS No: 4431-01-0; 81944-09-4
Price: $70/20mg

Militarine

Catalog No: CFN90409
CAS No: 58139-23-4
Price: $118/20mg

Description:

Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level.

Targets:

Calcium Channel

In vitro:

Biochim Biophys Acta. 2008 Dec;1780(12):1388-94.

The alpha-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca2+ fluxes and gene expression.[Pubmed: 18708125]

An alpha-L-Rhamnose specific lectin site was described on human skin keratinocytes and fibrobasts. The addition of Rhamnose-rich oligo- and polysaccharides (RROPs) to fibroblasts has been shown to stimulate cell proliferation and increase extracellular matrix biosynthesis, suggesting that this lectin site functions as a "true" receptor transmitting messages to the cell interior.
METHODS AND RESULTS:
It was confirmed here that addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level. The Rhamnose-rich oligosaccharide RROP-3 as well as l-Rhamnose alone were also able to trigger similar intracellular free Ca2 concentration increases in NHDFs. Moreover, the recording of the RROP-1-induced modification of the gene-expression profile in fibroblasts showed that this polysaccharide triggered a down-regulation of the expression of several growth factors, adhesion molecules and extracellular matrix proteins involved in pro-tumoral activity and/or fibrotic processes.
CONCLUSIONS:
These results further support the hypothesis of a receptor function for the Rhamnose-recognizing lectin site in fibroblasts. Anti-fibrotic and anti-tumoral potential of RROP-1 remains to be further explored.

alpha-L-Rhamnose Description

Source:	The leaves of Rhus toxicodendron
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioorg Med Chem. 2013 Nov 1;21(21):6778-87.

Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation.[Pubmed: 23988485]

METHODS AND RESULTS:
A novel and efficient strategy for the synthesis of phosphoramidon and its β anomer has been developed by manipulating the anomerization of alpha-L-Rhamnose triacetate upon phosphitylation. The experimental results suggest that proton transfer, bond rotation, and N atom are the key factors for the anomerization.
CONCLUSIONS:
The determined Ki and Kd values establish that phosphoramidon prepared by this method possesses excellent biological activity, and indicate that the contacts of rhamnose moiety with the enzyme have limited contribution to the binding.

Product Name	alpha-L-Rhamnose
Price:	$30 / 20mg
CAS No.:	3615-41-6
Catalog No.:	CFN90450
Molecular Formula:	C₆H₁₂O₅
Molecular Weight:	164.16 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The leaves of Rhus toxicodendron
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	121.8324 mL	152.2904 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	24.3665 mL	30.4581 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	12.1832 mL	15.229 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	2.4366 mL	3.0458 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2183 mL	1.5229 mL

CFN90954	D-(+)-Fucose	3615-37-0	164.16	C₆H₁₂O₅
CFN99769	D-(+)-Glucose	50-99-7	180.16	C₆H₁₂O₆
CFN91487	Glucuronic acid	6556-12-3	194.1	C₆H₁₀O₇
CFN91731	D-Galactose	59-23-4	180.16	C₆H₁₂O₆
CFN91488	Galacturonic acid	91510-62-2	194.1	C₆H₁₀O₇
CFN98407	Ethyl glucoside	3198-49-0	208.2	C₈H₁₆O₆
CFN99650	Eleutheroside C	15486-24-5	208.2	C₈H₁₆O₆
CFN99194	D-Glucosamine hydrochloride	66-84-2	215.63	C₆H₁₃NO₅.HCl
CFN99885	6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone	19131-13-6	320.3	C₁₄H₂₄O₈
CFN93288	Kinsenoside	151870-74-5	264.2	C₁₀H₁₆O₈