g-Strophanthin | CAS:630-60-4 | Manufacturer ChemFaces

g-Strophanthin

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Description:

g-Strophanthin can change the action potential, which is secondary events caused by the change of active Na+ transport.

Targets:

Potassium Channel | Sodium Channel | ATPase

In vitro:

Archives internationales de pharmacodynamie et de therapie, 1978, 232(2):291.

Actions of G-strophanthin, adrenaline and acetylcholine on bullfrog ventricular muscle in the sodium-free lithium solution.[Reference: WebLink]

METHODS AND RESULTS:
The actions of g-Strophanthin, adrenaline and acetylcholine on the action potential of bullfrog ventricular muscle were studied in the Na+ -free Li+ solution, in order to examine if these actions are associated with the change of active Na+ transport. The action of g-Strophanthin on the action potential, being observed in the Ringer solution, completely disappeared in the Na+-free Li+ solution. On the other hand, the actions of adrenaline and acetylcholine remained unchanged in the Na+ -free Li+ solution, except the hyperpolarizing action of adrenaline on the resting membrane.
CONCLUSIONS:
These results suggest that changes of the action potential by g-Strophanthin are secondary events caused by the change of active Na+ transport, whereas those by adrenaline and acetylcholine are primary events due to the change of membrane permeability.

g-Strophanthin Description

Source:	The herbs of Thevetia peruviana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nature New Biology, 1971, 234(47):122-124.

Mutual exclusion of ATP, ADP and g-strophanthin binding to NaK-ATPase.[Reference: WebLink]

METHODS AND RESULTS:
An investigation of the binding of the glycoside g-Strophanthin and of the substrate ATP to brain microsomal ATPase, described here, has shown that the number of binding sites for g-Strophanthin and ATP is identical and suggests that the glycosides inhibit the function of the enzyme by preventing the binding of ATP.The binding capacity for ATP and g-Strophanthin was determined on microsomal ATPase from ox brain prepared as described before7. The number of ATP-binding sites was measured by a rapid dialysis rate technique8,9, using 32P-ATP (Radiochemical Centre, Amersham) purified by chromatography9.
CONCLUSIONS:
To depress the hydrolysis of ATP, binding studies were carried out at 2° C in the presence of 10 mM EDTA to chelate any magnesium contaminating the preparations. No sodium or potassium was added.

Product Name	g-Strophanthin
Price:
CAS No.:	630-60-4
Catalog No.:	CFN70427
Molecular Formula:	C₂₉H₄₄O₁₂
Molecular Weight:	584.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Thevetia peruviana
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library Sodium Channel Inhibitor Library Potassium Channel Inhibitor Library ATPase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7103 mL	8.5514 mL	17.1028 mL	34.2056 mL	42.757 mL
5 mM	0.3421 mL	1.7103 mL	3.4206 mL	6.8411 mL	8.5514 mL
10 mM	0.171 mL	0.8551 mL	1.7103 mL	3.4206 mL	4.2757 mL
50 mM	0.0342 mL	0.171 mL	0.3421 mL	0.6841 mL	0.8551 mL
100 mM	0.0171 mL	0.0855 mL	0.171 mL	0.3421 mL	0.4276 mL

CFN96147	Thevetin B	27127-79-3	859.0	C₄₂H₆₆O₁₈
CFN70427	g-Strophanthin	630-60-4	584.7	C₂₉H₄₄O₁₂
CFN70435	Strophanthidine	66-28-4	404.5	C₂₃H₃₂O₆
CFN70428	Helveticoside	630-64-8	534.7	C₂₉H₄₂O₉
CFN70386	Cymarin	508-77-0	548.7	C₃₀H₄₄O₉
CFN70385	Convallatoxin	508-75-8	550.7	C₂₉H₄₂O₁₀
CFN70338	k-Strophanthoside	33279-57-1	873.0	C₄₂H₆₄O₁₉
CFN91787	Deslanoside	17598-65-1	943.09	C₄₇H₇₄O₁₉
CFN96196	Lanatoside C	17575-22-3	985.1	C₄₉H₇₆O₂₀
CFN93081	Periplocymarin	32476-67-8	534.69	C₃₀H₄₆O₈