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Natural Products
Catalog No. Information
CFN99987 Saikosaponin A

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-inflammatory, immunomodulatory, and anti-bacterial activities. It extends to alcohol self-administration the capacity to suppress morphine and cocaine self-administration in rats, and can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.
CFN99127 Saikosaponin B1

Saikosaponin B1 may be as anti-schizophrenic candidate drugs, it can suppress the signal transduction after binding of EGF.
CFN99126 Saikosaponin B2

Saikosaponin B2 as an efficient inhibitor of early HCV entry, including neutralization of virus particles, preventing viral attachment, and inhibiting viral entry/fusion. It (5 microM) induces differentiation of B16 melanoma cells, with potentiation of expressions of melanogenesis and tyrosinase.
CFN80311 Saikosaponin B3

Saikosaponin B3 shows some analgesic effect.
CFN93258 Saikosaponin B4

Saikosaponin B4 can selectively inhibit ACTH-induced lipolysis.
CFN99988 Saikosaponin C

Saikosaponin C exhibits anti-HBV activity, it has the potential for therapeutic angiogenesis but is not suitable for cancer therapy, it also might be a novel therapeutic tool for treating human AD and other neurodegenerative diseases. It inhibited caspase-3 activation and caspase-3-mediated-FAK degradation, induced matrix metalloproteinase-2 (MMP-2)、vascular endothelial growth factor (VEGF) 、the p42/p44 mitogen-activated protein kinase (MAPK, ERK).
CFN99989 Saikosaponin D

Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is also an agonist of the glucocorticoid receptor (GR),which has anti-cancer, anti-inflammatory, and neuroprotective effects. Saikosaponin D protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling; it shows inhibitory effects on NF-κB activation and thereby on iNOS, COX-2 and pro-inflammatory cytokines.
CFN93270 Saikosaponin E

Reference standards.
CFN90635 Saikosaponin F

Saikosaponin F shows anti-inflammatory effect against carrageenan-induced plantar oedema in the rat.
CFN90902 Saikosaponin H

Saikosaponin H is a natural product from Bupleurum chinense.