1. Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
1. Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics; however, topically applied aloe emodin increases the sensitivity of skin to UV light, although aloin A is not directly photocytotoxic, but human skin fibroblasts can metabolize aloin A to aloe emodin.
2. Aloin A and aloe emodin have antibacterial activity against Gram-positive and Gram-negative bacteria.
1. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation, the result opens new vistas for the use of A. vera regarding its clinical application as a new nontoxic melanolytic agent for the treatment of hyperpigmentation.
2. Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor.
1. Alpha-Amyrin is an antineoplastic agent.
2. Alpha-Amyrin is trypsin and chymotrypsin inhibitor.
3. Alpha-Amyrin induces proliferation of human keratinocytes.
4. Alpha-Amyrin can as a hepatomodulatory potent to feasibility for a promising liver curative drug.
1. alpha-Boswellic acid (α-BA)has gastroprotective properties, α-BA decreases oxidative stress and that the Nrf2/HO-1 pathway might play a role in the gastroprotective action of α-BA in ethanol-induced gastric injury in rats.
2. alpha-Boswellic acid could be considered as a potent therapeutic agent for prevention and decreasing the progression of Alzheimer’s hallmarks, it can efficiently reduce hyperphosphorylated Tau (Ser404) in STZ-treated astrocytes and decrease ROS generation and promote proliferation of astrocytes through elevating Survivin expression.
3. Boswellic acid has protective effects against acetaminophen (APAP)-induced hepatotoxicity in Balb/ cA mice.
1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.
3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.
1. Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth.
2. Alpha-humulene and trans-caryophyllene show marked anti-inflammatory effects, probably by interfering with TNFalpha production .
1. Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis.
2. The cytotoxic effects of α-Solanine and alpha-Chaconine were observed immediately after incubation and were constant after 30min, suggesting that rapid damage of plasma membrane causes the lethal disorder of metabolism.
1. Alpha-cyperone has anti-inflammatory effects with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells.
2. Alpha-cyperone can protect lung cells from Hla-induced injury , indicates that alpha-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium.
3. Alpha-cyperone inhibits the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-kappa B signaling pathways, it may contribute to future research on the action mechanisms, as well as therapy for inflammation- or coagulation-related diseases.
4. Alpha-cyperone shows inhibitory effects on adherence and invasion of avian pathogenic Escherichia coli O78 to chicken type II pneumocytes.
1. Alpha-hederin has anticancer effect on breast cancer cells.
2. Alpha-hederin has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema.
3. Alpha-hederin, chlorophyllin and ascorbic acid have protective effects towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.
4. Alpha-hederin has antileishmanial activity ,exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania .
5. Alpha-hederin affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.
6. Alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like .
7. Alpha-hederin shows antifungal activity.
8. Alpha-hederin at sub-IC(50) cytotoxic concentrations enhances 5-fluorouracil (5-FU) cytotoxicity about 3.3-fold, suggests that it is possible to optimize colorectal cancer cell sensitivity to 5-FU with alpha-hederin.