1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.
3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.
1. Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth.
2. Alpha-humulene and trans-caryophyllene show marked anti-inflammatory effects, probably by interfering with TNFalpha production .
1. Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis.
2. The cytotoxic effects of α-Solanine and alpha-Chaconine were observed immediately after incubation and were constant after 30min, suggesting that rapid damage of plasma membrane causes the lethal disorder of metabolism.
1. Alpha-Cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium.
2. Alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced expression of inducible COX-2 at both the mRNA and the protein levels , downregulated the production and mRNA expression of the inflammatory cytokine IL-6.
3. Alpha-Cyperone inhibited actin cytoskeleton polymerization induced by APEC-O78 through down regulating the expression of Nck-2, Cdc42 and Rac1.
1. Alpha-hederin is a haemolytic agent.
2. Alpha-hederin has potential anti-inflammatory activity.
3. Alpha-hederin shows molluscicidal activity and antifungal activity.
1. Alpha-mangostin has antioxidant and anti-inflammatory activities.
2. Alpha-mangostin has strong antifungal activity and low toxicity to make it a promising agent for treatment of oral candidiasis.
3. Alpha-mangostin exhibits peripheral and central antinociception through modulation of opioid and vanilloid receptors, the glutamatergic system, and the larginine/NO/cGMP/PKC/K(+)-ATP pathways.
4. Alpha-mangostin has anti-cancer activity, can reduce cell proliferation and inhibit tumorigenesis, by inducing apoptosis via the mitochondrial pathway1, blockade of Stat3 signaling pathway, and inhibiting Fatty acid synthase (FAS).
1. Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
2. Alpha-Solanine has proliferation-inhibiting and apoptosis-promoting effect on multiple cancer cells, such as clone, liver, melanoma cancer cells.
1. Alpha-Spinasterol is characterized by good blood-brain permeability.
2. Alpha-Spinasterol is a novel efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect.
3. Alpha-Spinasterol can prevent TP-induced prostatic hyperplasia and may be beneficial in the management of benign prostatic hyperplasia.
1. Alpha-Tocopherolquinone has a favorable pharmacokinetic profile when administered orally with food.
2. Alpha-Tocopherolquinone cannot replace endogenous ubiquinones in the respiratory chain function, nevertheless it can be reduced by the mitochondrial respiratory chain substrates, presumably through the reduced ubiquinones.
3. Alpha-Tocopherolquinone has antioxidant effect, can inhibit lipid peroxidation and reduce cell division in both the glioma cell clone and fetal brain cells.
1. Alpha-Viniferin inhibits AChE activity is specific, reversible and noncompetitive, in a dose-dependent manner, and the IC50 values of alpha-Viniferin were 2.0 microM.
2. Alpha-Viniferin exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 microM.
3. Alpha-Viniferin has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.