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    Natural Products
    Catalog No. Information
    CFN97220 Acanthoside B

    1.Acanthoside has inhibitory effects on the allergic inflammation.
    CFN90523 Acetyl shikonin

    1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors.
    2. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated.
    3. Certain shikonin derivatives(such as Acetyl shikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction.
    4. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats.
    5. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge.
    6. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
    CFN90308 Acetylshikonin

    1. Acetylshikonin (ASK), a derivate of shikonin, can effectively inhibit tumor cells.
    2. Acetylshikonin can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus.
    3. Acetylshikonin exhibits the most potent antiapoptosis activity through the inhibition of the generation of reactive oxygen species as well as protection of the loss of mitochondria membrane potential.
    4. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
    CFN90248 Aconine

    1. Aconine is the febrifuge.
    2. Aconine possesses gastric anaesthetic props.
    CFN99915 Aconitine

    1. Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, in the causation of severe arrhythmias leading to death.
    2. Aconitine appears to exert a long-lasting cholinergic action which may be involved in the genesis of aconitine-induced atrial fibrillation.
    CFN97048 Acteoside

    1. Acteoside is a lipase inhibitor, has anti-obesity properties.
    2. Acteoside has neuroprotective activity, can promote nerve growth factor and tropomycin receptor kinase A expression.
    3. Acteoside has anti-inflammatory activity, it significantly inhibits arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin.
    4. Acteoside has antioxidant activity, can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways.
    5. Acteoside exhibits anticancer, cytotoxic and antimetastatic activities, it is an antiestrogen in breast cancer cells and osteoblasts.
    6. Acteoside has protective effects against the carbon tetrachloride-induced hepatotoxicity, the mechanisms possibly related to its ability to block the P450-mediated carbon tetrachloride bioactivation and free radical scavenging effects.
    7. Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte.
    8. Acteoside and its analogs have antioxidant and antihypertensive activities, it is a new antihypertensive drug.
    9. Acteoside has analgesic activity, it as the Analgesic Principle of Cedron (Lippia hriphylla), a Peruvian Medicinal Plant.
    CFN99215 Adenanthin

    1. Adenanthin has bacteriostatic activity.
    2. Adenanthin has antiinflammatory activity.
    3. Adenanthin has antitumour activity .
    4. Adenanthin is a novel NF-κB and nucleophilic cysteines inhibitor.
    5. Adenanthin has antileukemic activity through targeting peroxiredoxin I/II.
    6. Adenanthin can serve as the development of Prx I– and Prx II–targeted therapeutic agents.
    CFN98992 Adenosine

    1. Adenosine induces SphK1 activity in human and mouse sickle and normal erythrocytes in vitro.
    2. Adenosine can activate the neuroimmune system, alter neuronal function and neurotransmission,and contribute to symptoms of sickness and psychopathologies, .
    3. Adenosine activates mast cells have been long implicated in allergic asthma and studies in rodent mast cells have assigned the A3 Adenosine receptor (A3R) a primary role in mediating Adenosine responses.
    CFN98757 Afzelin

    1. Afzelin has antibacterial effects on Pseudomonas aeruginosa, its minimum inhibitory concentration (MIC) is 31ug/mL.
    2. Afzelin has several cellular activities such as DNA-protective, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities.
    3. Afzelin has potenial anti-cancer activity against prostate cancer, the activity is due to inhibition of LIM domain kinase 021 expression, it can inhibit the proliferation of LNCaP and PC302cells, and block the cell cycle in the G002phase.
    4. Afzelin can attenuate asthma phenotypes is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production.
    5. Afzelin may be useful as a protective agent against ultraviolet irradiation, it promotes melanogenesis by occurs through increased MITF gene expression, which is mediated by activation of p38 MAPK.
    CFN99203 Agnuside

    1. Agnuside has anti-arthritic activity.
    2. Agnuside shows inhibition of vascular permeability and leukocyte migration in vivo.