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    Natural Products
    Catalog No. Information
    CFN92011 9-Methoxycanthin-6-one

    1. 9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.
    CFN90587 Abietic acid

    1. Abietic acid, a naturally occurring compound, can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis.
    2. Abietic acid acts as a PPARα/γ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-κB and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing.
    CFN90168 Absinthiin

    1. Absinthin is a natural bitter flavoring constituent.
    CFN98744 Acacetin

    1. Acacetin has anti-peroxidative and anti-inflammatory effects, it can suppress LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice.
    2. Acacetin is an atrium-selective agent that prolongs the atrial effective refractory period without prolonging the corrected QT interval and effectively prevents atrial fibrillation (AF) in anesthetized dogs after intraduodenal administration.
    3. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo, it may act as a potential therapeutic agent for brain diseases involving neuroinflammation.
    4. Dietary acacetin can reduce airway hyperresponsiveness and eosinophil infiltration by modulating eotaxin-1 and th2 cytokines in a mouse model of asthma, suggests that dietary may improve symptoms in -sensitized.
    5. Acacetin has spasmolytic and antinociceptive activities.
    6. Acacetin has anti-cancer and antitumor activities, such as prostate cancer, melanoma angiogenesis tumor , via Akt/NF-κB,Stat signaling pathway.
    CFN97220 Acanthoside B

    1.Acanthoside has inhibitory effects on the allergic inflammation.
    CFN90523 Acetyl shikonin

    1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors.
    2. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated.
    3. Certain shikonin derivatives(such as Acetyl shikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction.
    4. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats.
    5. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge.
    6. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
    CFN90308 Acetylshikonin

    1. Acetylshikonin (ASK), a derivate of shikonin, can effectively inhibit tumor cells.
    2. Acetylshikonin can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus.
    3. Acetylshikonin exhibits the most potent antiapoptosis activity through the inhibition of the generation of reactive oxygen species as well as protection of the loss of mitochondria membrane potential.
    4. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
    CFN90248 Aconine

    1. Aconine can inhibit RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression.
    2. Aconine has GW26-e4470 effect on the expression of Sirt-1 and eNOS system in EAhy926 cell injured by Homocysteine.
    3. Aconine can attenuate hepatic fat degeneration of rats with fatty liver induced by high-fat diet through decreasing TG,TC deposit in liver.
    CFN99915 Aconitine

    1. Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, in the causation of severe arrhythmias leading to death.
    2. Aconitine appears to exert a long-lasting cholinergic action which may be involved in the genesis of aconitine-induced atrial fibrillation.
    CFN97048 Acteoside

    1. Acteoside is a lipase inhibitor, has anti-obesity properties.
    2. Acteoside has neuroprotective activity, can promote nerve growth factor and tropomycin receptor kinase A expression.
    3. Acteoside has anti-inflammatory activity, it significantly inhibits arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin.
    4. Acteoside has antioxidant activity, can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways.
    5. Acteoside exhibits anticancer, cytotoxic and antimetastatic activities, it is an antiestrogen in breast cancer cells and osteoblasts.
    6. Acteoside has protective effects against the carbon tetrachloride-induced hepatotoxicity, the mechanisms possibly related to its ability to block the P450-mediated carbon tetrachloride bioactivation and free radical scavenging effects.
    7. Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte.
    8. Acteoside and its analogs have antioxidant and antihypertensive activities, it is a new antihypertensive drug.
    9. Acteoside has analgesic activity, it as the Analgesic Principle of Cedron (Lippia hriphylla), a Peruvian Medicinal Plant.