1. Allantoin has anti-oxidative and anti-inflammatory activities.
2. Allantoin can enhance the antifungal activity of Nanoencapsulation.
3. Allantoin, as I-1R agonist, has the potential to develop as a new therapeutic agent for hypertension in the future.
1. Allicin exerts a unique bactericidal effect on biofilm-embedded bacteria.
2. Allicin can treat cancer via alleviating liver injury by as an adjuvant to Tamoxifen .
3. Allicin has protective effects on H9c2 cells, could inhibit intracellular ROS production instead of scavenging extracellular H(2)O(2) or free radicals.
4. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path.
5. Allicin may inhibit the proliferation and induce the apoptosis of MGC‑803 human gastric carcinoma cells, and this may partially be achieved through the enhanced expression of p38 and cleaved caspase 3.
1. Alnustone exerts significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.
1. Aloeemodin (AE) has a specific in vitro and in vivo anti-neuroectodermal tumor activity.
2. Aloeemodin reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species.
3. Aloeemodin appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation.
4. Aloeemodin has a strong stimulant-laxative action; is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of some kind of radiation.
1. Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
1. Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics; however, topically applied aloe emodin increases the sensitivity of skin to UV light, although aloin A is not directly photocytotoxic, but human skin fibroblasts can metabolize aloin A to aloe emodin.
2. Aloin A and aloe emodin have antibacterial activity against Gram-positive and Gram-negative bacteria.
1. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation, the result opens new vistas for the use of A. vera regarding its clinical application as a new nontoxic melanolytic agent for the treatment of hyperpigmentation.
2. Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor.
1. Alpha-Amyrin is an antineoplastic agent.
2. Alpha-Amyrin is trypsin and chymotrypsin inhibitor.
3. Alpha-Amyrin induces proliferation of human keratinocytes.
4. Alpha-Amyrin can as a hepatomodulatory potent to feasibility for a promising liver curative drug.
1. alpha-Boswellic acid (α-BA), a pentacyclic triterpene compound from extracts of Frankincense, has gastroprotective properties, α-BA decreases oxidative stress and that the Nrf2/HO-1 pathway might play a role in the gastroprotective action of α-BA in ethanol-induced gastric injury in rats.
2. alpha-Boswellic acid can efficiently reduce hyperphosphorylated Tau (Ser404) in STZ-treated astrocytes and decrease ROS generation and promote proliferation of astrocytes through elevating Survivin expression, suggests that α-BA could be considered as a potent therapeutic agent for prevention and decreasing the progression of Alzheimer’s hallmarks in astrocytes; however, more in vivo studies would be needed.
3. Boswellic acid has protective effects against acetaminophen (APAP)-induced hepatotoxicity in Balb/ cA mice.
1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.
3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.