1. Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth.
2. Alpha-humulene and trans-caryophyllene show marked anti-inflammatory effects, probably by interfering with TNFalpha production .
1. Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis.
2. The cytotoxic effects of α-Solanine and alpha-Chaconine were observed immediately after incubation and were constant after 30min, suggesting that rapid damage of plasma membrane causes the lethal disorder of metabolism.
1. Alpha-cyperone has anti-inflammatory effects with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells.
2. Alpha-cyperone can protect lung cells from Hla-induced injury , indicates that alpha-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium.
3. Alpha-cyperone inhibits the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-kappa B signaling pathways, it may contribute to future research on the action mechanisms, as well as therapy for inflammation- or coagulation-related diseases.
4. Alpha-cyperone shows inhibitory effects on adherence and invasion of avian pathogenic Escherichia coli O78 to chicken type II pneumocytes.
1. Alpha-hederin has anticancer effect on breast cancer cells.
2. Alpha-hederin has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema.
3. Alpha-hederin, chlorophyllin and ascorbic acid have protective effects towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.
4. Alpha-hederin has antileishmanial activity ,exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania .
5. Alpha-hederin affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.
6. Alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like .
7. Alpha-hederin shows antifungal activity.
8. Alpha-hederin at sub-IC(50) cytotoxic concentrations enhances 5-fluorouracil (5-FU) cytotoxicity about 3.3-fold, suggests that it is possible to optimize colorectal cancer cell sensitivity to 5-FU with alpha-hederin.
1. alpha-Mangostin has antioxidant and anti-inflammatory activities.
2. alpha-Mangostin has strong antifungal activity and low toxicity to make it a promising agent for treatment of oral candidiasis.
3. alpha-Mangostin exhibits peripheral and central antinociception through modulation of opioid and vanilloid receptors, the glutamatergic system, and the larginine/NO/cGMP/PKC/K(+)-ATP pathways.
4. alpha-Mangostin has anti-cancer activity, can reduce cell proliferation and inhibit tumorigenesis, by inducing apoptosis via the mitochondrial pathway1, blockade of Stat3 signaling pathway, and inhibiting Fatty acid synthase (FAS).
5. alpha-Mangostin induces caspase-3-dependent apoptosis in HL60 cells, it and its analogs would be candidates for preventive and therapeutic application for cancer treatment.
6. alpha-Mangostin inhibits Ca2+-ATPase to cause apoptosis through the mitochondrial pathway.
7. alpha-Mangostin is a novel competitive histamine H1 receptor antagonist in smooth muscle cells.
8. alpha-Mangostin has a neuroprotective effect against 3-nitropropionic acid (3-NP) in primary cultures of CGNs, which is associated with its ability to ameliorate 3-NP-induced ROS production.
9. alpha-Mangostin has renoprotection, which is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity.
10. alpha-Mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.
1. Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
2. Alpha-Solanine has proliferation-inhibiting and apoptosis-promoting effect on multiple cancer cells, such as clone, liver, melanoma cancer cells.
1. Alpha-Spinasterol has anti-inflammatory activity.
2. Alpha-Spinasterol is a novel efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect.
3. Alpha-Spinasterol can prevent TP-induced prostatic hyperplasia and may be beneficial in the management of benign prostatic hyperplasia.
4. Alpha-Spinasterol is a potent inhibitor (IC(50)= 3.9 x 10 (-12) g/mL, 9.5 pmol/L) of glomerular mesangial cell proliferation caused by high-ambient glucose (5.6 mM vs. 25 mM), it has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.
1. Alpha-Tocopherolquinone has a favorable pharmacokinetic profile when administered orally with food.
2. Alpha-Tocopherolquinone cannot replace endogenous ubiquinones in the respiratory chain function, nevertheless it can be reduced by the mitochondrial respiratory chain substrates, presumably through the reduced ubiquinones.
3. Alpha-Tocopherolquinone has antioxidant effect, can inhibit lipid peroxidation and reduce cell division in both the glioma cell clone and fetal brain cells.
4. Alpha-Tocopherolquinone inhibits β-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines.
1. Alpha-viniferin has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
2. Alpha-Viniferin exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 microM.
3. Alpha-Viniferin has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
4. Alpha-Viniferin inhibits AChE activity is specific, reversible and noncompetitive, in a dose-dependent manner, and the IC50 values of alpha-Viniferin were 2.0 microM.
5. Alpha-viniferin is a prostaglandin H2 synthase inhibitor, the inhibitory potency of (+)-alpha-viniferin is about 3- to 4-fold stronger than that of resveratrol on cyclooxygenase activity of prostaglandin H2 synthase partially purified from sheep seminal vesicles.
1. Alphitolic acid is an anti-inflammatory triterpene, has antitumour activity in oral squamous cell carcinoma (OSCC) cells.
2. Alphitolic acid can suppress the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 uM, respectively, via apoptotic induction, this drug effect on apoptosis is, in part, associated with its ability to block Akt-NF-κB signalling; it could as an ingredient in functional food/dietary supplement for OSCC prevention.
3. Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells.
4. Alphitolic acid shows antimicrobial activity on Gram-positive bacteria and yeasts.
5. Alphitolic acid can inhibit NO release and iNOS expression in LPS-stimulated J774.A1 cultured macrophages.