1-Hydroxy-2-oxopomolic acid | CAS:217466-37-0

1-Hydroxy-2-oxopomolic acid

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1-Hydroxy-2-oxopomolic acid Description

Source:	The herbs of Agrimonia pilosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2012;35(5):643-9.

1β-Hydroxy-2-oxopomolic acid isolated from Agrimonia pilosa extract inhibits adipogenesis in 3T3-L1 cells.[Pubmed: 22687396]

METHODS AND RESULTS:
In order to determine anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (1-Hydroxy-2-oxopomolic acid, HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c (ADD1/SREBP1c), resistin, and fatty acid synthase (Fas) in 3T3-L1 preadipocyte. We demonstrated that HOA induced a significant decrease in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, HOA reduced the transcripitional activity of PPARγ induced by troglitazone, a potent diabetes agent; it also suppressed expression of PPARγ and C/EBPα protein levels.
CONCLUSIONS:
Our data suggest that HOA isolated from Agrimonia pilosa inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.

Product Name	1-Hydroxy-2-oxopomolic acid
Price:
CAS No.:	217466-37-0
Catalog No.:	CFN98080
Molecular Formula:	C₃₀H₄₆O₆
Molecular Weight:	502.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Agrimonia pilosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-adipogenic Compound Library Triterpenoids Compound Library PPAR Inhibitor Library GLUT Inhibitor Library Fatty Acid Synthase Inhibitor Library

Description:	1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
Targets:	PPAR \| GLUT \| Fatty Acid Synthase

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9893 mL	9.9463 mL	19.8926 mL	39.7852 mL	49.7315 mL
5 mM	0.3979 mL	1.9893 mL	3.9785 mL	7.957 mL	9.9463 mL
10 mM	0.1989 mL	0.9946 mL	1.9893 mL	3.9785 mL	4.9731 mL
50 mM	0.0398 mL	0.1989 mL	0.3979 mL	0.7957 mL	0.9946 mL
100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.3979 mL	0.4973 mL

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CFN99233	1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	113558-03-5	504.7	C₃₀H₄₈O₆
CFN98080	1-Hydroxy-2-oxopomolic acid	217466-37-0	502.7	C₃₀H₄₆O₆
CFN92211	3-O-cis-p-Coumaroyltormentic acid	121072-40-0	634.9	C₃₉H₅₄O₇
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CFN98095	2,3-O-Isopropylidenyl euscaphic acid	220880-90-0	528.8	C₃₃H₅₂O₅
CFN99310	2-Epitormentic acid	119725-19-8	488.7	C₃₀H₄₈O₅
CFN98920	2-Oxopomolic acid	54963-52-9	486.7	C₃₀H₄₆O₅