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1-Methyl-2-nonylquinolin-4(1H)-one
1-Methyl-2-nonylquinolin-4(1H)-one
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 1-Methyl-2-nonylquinolin-4(1H)-one
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CAS No.: 68353-24-2
Catalog No.: CFN96290
Molecular Formula: C19H27NO
Molecular Weight: 285.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The fruits of Evodia rutaecarpa (Juss.) Benth.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
In vitro:
Planta Med. 2004 Oct;70(10):904-8.
Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa.[Pubmed: 15490316]

METHODS AND RESULTS:
The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone(1-Methyl-2-nonylquinolin-4(1H)-one), 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively.
CONCLUSIONS:
Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.
1-Methyl-2-nonylquinolin-4(1H)-one Description
Source: The fruits of Evodia rutaecarpa (Juss.) Benth.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5039 mL 17.5193 mL 35.0385 mL 70.0771 mL 87.5964 mL
5 mM 0.7008 mL 3.5039 mL 7.0077 mL 14.0154 mL 17.5193 mL
10 mM 0.3504 mL 1.7519 mL 3.5039 mL 7.0077 mL 8.7596 mL
50 mM 0.0701 mL 0.3504 mL 0.7008 mL 1.4015 mL 1.7519 mL
100 mM 0.035 mL 0.1752 mL 0.3504 mL 0.7008 mL 0.876 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Garcinone E

Catalog No: CFN92697
CAS No: 112649-21-5
Price: $ / mg
Polygalacin D

Catalog No: CFN93351
CAS No: 66663-91-0
Price: $/mg
Isoliensinine

Catalog No: CFN99574
CAS No: 6817-41-0
Price: $80/20mg
Berberine

Catalog No: CFN98049
CAS No: 2086-83-1
Price: $40/20mg
Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg
Isosilybin A

Catalog No: CFN91070
CAS No: 142796-21-2
Price: $218/5mg
Apigenin

Catalog No: CFN98843
CAS No: 520-36-5
Price: $40/20mg
Tricetin

Catalog No: CFN70392
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Tectorigenin

Catalog No: CFN99920
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Apiin

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Price: $248/20mg
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