1-Methyl-2-nonylquinolin-4(1H)-one | CAS:68353-24-2

1-Methyl-2-nonylquinolin-4(1H)-one

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Description:

1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.

In vitro:

Planta Med. 2004 Oct;70(10):904-8.

Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa.[Pubmed: 15490316]

METHODS AND RESULTS:
The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone(1-Methyl-2-nonylquinolin-4(1H)-one), 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively.
CONCLUSIONS:
Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.

1-Methyl-2-nonylquinolin-4(1H)-one Description

Source:	The fruits of Evodia rutaecarpa (Juss.) Benth.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1-Methyl-2-nonylquinolin-4(1H)-one
Price:
CAS No.:	68353-24-2
Catalog No.:	CFN96290
Molecular Formula:	C₁₉H₂₇NO
Molecular Weight:	285.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The fruits of Evodia rutaecarpa (Juss.) Benth.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5039 mL	17.5193 mL	35.0385 mL	70.0771 mL	87.5964 mL
5 mM	0.7008 mL	3.5039 mL	7.0077 mL	14.0154 mL	17.5193 mL
10 mM	0.3504 mL	1.7519 mL	3.5039 mL	7.0077 mL	8.7596 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	1.4015 mL	1.7519 mL
100 mM	0.035 mL	0.1752 mL	0.3504 mL	0.7008 mL	0.876 mL

CFN91687	1-Methyl-2-[(6Z,9Z)-6,9-pentadecadiene]-4(1H)-quinolone	120693-52-9	365.6	C₂₅H₃₅NO
CFN90072	Kynurenic acid	492-27-3	189.17	C₁₀H₇NO₃
CFN97215	1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid	73281-83-1	217.2	C₁₂H₁₁NO₃
CFN96756	Ifflaiamine	31520-95-3	243.30	C₁₅H₁₇NO₂
CFN97248	Mallorepine	767-98-6	134.1	C₇H₆N₂O
CFN98213	Antidesmone	222629-77-8	319.4	C₁₉H₂₉NO₃
CFN89240	1-Hydroxyacridone	65582-54-9	211.22	C₁₃H₉NO₂
CFN96973	1,7-Dihydroxyacridone	112649-95-3	227.21	C₁₃H₉NO₃
CFN89268	1-Hydroxy-N-methylacridone	16584-54-6	225.24	C₁₄H₁₁NO₂
CFN99297	1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one	1189362-86-4	271.3	C₁₅H₁₃NO₄