1-Phenylethanol | CAS:98-85-1 | Manufacturer ChemFaces

1-Phenylethanol

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Description:

1-Phenylethanol has a nongenotoxic mode of action responsible for the lung and liver tumors observed in mice following 2 years of inhalation exposure to ethylbenzene.

In vivo:

Archives of toxicology, 2006, 80(12):868-872.

In vivo micronucleus test in mice with 1-phenylethanol.[Reference: WebLink]

1-Phenylethanol is one of the major primary phase-I metabolites of ethylbenzene. In principle it may yield an electrophilic intermediate by phase-II metabolism. Because of the extensive use of ethylbenzene as a solvent, 2-year carcinogenicity inhalation studies were carried out leading to renal hyperplasia and tubular neoplasms both in male and female rats and alveolar/bronchiolar neoplasms in male mice and hepatocellular neoplasms in female mice. Whereas the mechanism underlying the increased renal tumor incidences in rats has been clarified, the mechanism of tumor formation (genotoxic or nongenotoxic mode of action) in the lung and liver of mice is still unclear.
METHODS AND RESULTS:
The genotoxicity data available to date for 1-Phenylethanol include in vitro studies using either bacteria (Salmonella reverse mutation assay, E. coli Pol A(+)/Pol A(-) test) or mammalian cells (mouse lymphoma assay, chromosome aberration test and sister chromatid exchanges using CHO cells). These experiments, however, did not always follow current standard procedures and some of the data obtained are compromised and not always convincing. The present database thus does not allow a definitive assessment of the in vitro genotoxic potential of 1-Phenylethanol. The in vitro database suggests that clastogenicity may be the most relevant genetic end point, and therefore an in vivo micronucleus assay in mouse bone marrow was carried out. The animals were given 1-Phenylethanol in single oral doses up to the maximum tolerated dose of 750 mg/kg body weight. Bone marrow was sampled 24 and 48 h after treatment. Under the experimental conditions used, there was no evidence of increased micronuclei frequencies at any dose or sampling time.
CONCLUSIONS:
These findings indicate that 1-Phenylethanol is not clastogenic in vivo. This information, together with other negative or inconclusive genotoxicity data available so far, suggests a nongenotoxic mode of action responsible for the lung and liver tumors observed in mice following 2 years of inhalation exposure to ethylbenzene.

1-Phenylethanol Description

Source:	The heartwoods of Platycladus orientalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1-Phenylethanol
Price:	$30 / 20mg
CAS No.:	98-85-1
Catalog No.:	CFN70233
Molecular Formula:	C₈H₁₀O
Molecular Weight:	122.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Oil
Source:	The heartwoods of Platycladus orientalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	8.1833 mL	40.9165 mL	81.8331 mL	163.6661 mL	204.5827 mL
5 mM	1.6367 mL	8.1833 mL	16.3666 mL	32.7332 mL	40.9165 mL
10 mM	0.8183 mL	4.0917 mL	8.1833 mL	16.3666 mL	20.4583 mL
50 mM	0.1637 mL	0.8183 mL	1.6367 mL	3.2733 mL	4.0917 mL
100 mM	0.0818 mL	0.4092 mL	0.8183 mL	1.6367 mL	2.0458 mL

CFN90886	Irinotecan hydrochloride	100286-90-6	623.2	C₃₃H₃₉ClN₄O₆
CFN60347	Thalidomide	50-35-1	258.23	C₁₃H₁₀N₂O₄
CFN60227	Ganetespib (STA-9090)	888216-25-9	364.4	C₂₀H₂₀N₄O₃
CFN60214	Sapitinib (AZD8931)	848942-61-0	473.93	C₂₃H₂₅ClFN₅O₃