10-Deacetyl-7-xylosyl paclitaxel | CAS:90332-63-1

10-Deacetyl-7-xylosyl paclitaxel

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Description:

10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).

In vitro:

Planta Med. 2010 Oct;76(14):1592-5.

Transport of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel, by human intestinal epithelial Caco-2 cells.[Pubmed: 20414861 ]

7-Xylosyl-10-deacetylpaclitaxel(10-Deacetyl-7-xylosyl paclitaxel) is an active compound used in traditional Chinese medicine to treat cancer. However, pharmacokinetic studies yielded low plasma concentrations of 7-xylosyl-10-deacetylpaclitaxel after its oral administration in preclinical trials. Therefore, we investigated whether the observed low oral bioavailability of this compound is due to poor absorption.
METHODS AND RESULTS:
We studied the transepithelial flux of 7-xylosyl-10-deacetylpaclitaxel using the human colonic cell line Caco-2 as a model and found out that its flux (at a concentration range of 0.5-20 μM) across the Caco-2 cell layer was linear with time for up to 3 hr. The apparent maximal concentration (K (M)) of the active efflux component was 93.4 μM. Verapamil (50 μM) and tetrandrine (25 μM) significantly decreased the active transport component.
CONCLUSIONS:
These data support the conclusion that rapid passive diffusion of 7-xylosyl-10-deacetylpaclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-xylosyl-10-deacetylpaclitaxel transport (16.3 ± 6.3 × 10 (-6) cm/s; n = 3) suggests that the drug may still be effectively absorbed in the intestinal tract.

10-Deacetyl-7-xylosyl paclitaxel Description

Source:	The barks of Taxus baccata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	10-Deacetyl-7-xylosyl paclitaxel
Price:	$118 / 20mg
CAS No.:	90332-63-1
Catalog No.:	CFN90837
Molecular Formula:	C₅₀H₅₇NO₁₇
Molecular Weight:	944.0 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Taxus baccata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0593 mL	5.2966 mL	10.5932 mL	21.1864 mL	26.4831 mL
5 mM	0.2119 mL	1.0593 mL	2.1186 mL	4.2373 mL	5.2966 mL
10 mM	0.1059 mL	0.5297 mL	1.0593 mL	2.1186 mL	2.6483 mL
50 mM	0.0212 mL	0.1059 mL	0.2119 mL	0.4237 mL	0.5297 mL
100 mM	0.0106 mL	0.053 mL	0.1059 mL	0.2119 mL	0.2648 mL

CFN89398	7-Xylosyltaxol B	90352-19-5	964.01	C₅₀H₆₁NO₁₈
CFN96640	Taxcultine	153415-46-4	819.90	C₄₄H₅₃NO₁₄
CFN89043	N-Methyltaxol C	153083-53-5	861.97	C₄₇H₅₉NO₁₄
CFN96633	Taxol C	153415-45-3	847.95	C₄₆H₅₇NO₁₄
CFN89385	7-Xylosyl-10-deacetyltaxol C	90332-65-3	938.02	C₄₉H₆₃NO₁₇
CFN89044	13-O-Cinnamoylbaccatin III	220932-65-0	716.77	C₄₀H₄₄O₁₂
CFN89140	Cabazitaxel intermediate	1354900-65-4	926.02	C₅₁H₅₉NO₁₅
CFN98517	Docetaxel	114977-28-5	807.88	C₄₃H₅₃NO₁₄
CFN98516	N-Debenzoyl-N-(tert-butoxycarbonyl)taxol	125354-16-7	849.92	C₄₅H₅₅NO₁₅
CFN98518	Cephalomannine	71610-00-9	831.91	C₄₅H₅₃NO₁₄