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- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
ChemFaces products have been cited in many studies from excellent and top scientific journals
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
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Our products had been exported to the following research institutions and universities, And still growing.
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- University of Hull (United Kingdom)
- Auburn University (USA)
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Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
(2R,3R)-2',3,5,6'7-pentahydroxyflavanone(2',3,5,6',7-Pentahydroxyflavanone) can inhibit the histamine release from rat mast cells induced by compound 48/80. It inhibits the lipid peroxide formation by Feand ascorbic acid, it also inhibits the lipid peroxide formation induced by adenosine diphosphate and reduces nicotinamide adenine dinucleotide phosphate in rat liver homogenate.
|
| Targets: |
NO |
| In vitro: |
| Chem. Pharm. Bull., 1984, 32(12):5051-4. | | Scutellariae radix. X. Inhibitory effects of various flavonoids on histamine release from rat peritoneal mast cells in vitro.[Reference: WebLink] | The effects of various flavonoids isolated from the roots of Scutellaria baicalensis on the histamine release from mast cells were investigated.
METHODS AND RESULTS:
Many of the flavonoids (wogonin, wogonin-7-O-D-glucuronide, baicalein, skullcapflavanone II, (2S)-2',5,6',7-tetrahydroxyflavanone, (2R,3R)-2',3,5,6',7-Pentahydroxyflavanone and 2',5,5',7-tetrahydroxy-6'-8-dimethoxyflavone) inhibited the histamine release from rat mast cells induced by compound 48/80. | | Chem Pharm Bull (Tokyo). 1982 May;30(5):1792-5. | | Studies on Scutellariae radix. VI. Effects of flavanone compounds on lipid peroxidation in rat liver.[Reference: WebLink] | Compounds (I and II) which inhibited lipid peroxides formation (in in vitro experiments) were isolated together with various flavonoids from the roots of Scutellaria baicalensis GEORGI.
METHODS AND RESULTS:
From the analytical and physical data, compounds I and II were identified as (2S)-2', 5, 6', 7-tetrahydroxyflavanone and (2R, 3R)-2',3,5,6',7-Pentahydroxyflavanone, respectively. Compound II inhibited the lipid peroxide formation by Feand ascorbic acid. Compounds I and II inhibited the lipid peroxide formation induced by adenosine diphosphate and reduced nicotinamide adenine dinucleotide phosphate in rat liver homogenate. |
|
2',3,5,6',7-Pentahydroxyflavanone Description
| Source: |
The roots of Scutellaria baicalensis Georgi |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.2862 mL |
16.4312 mL |
32.8623 mL |
65.7246 mL |
82.1558 mL |
| 5 mM |
0.6572 mL |
3.2862 mL |
6.5725 mL |
13.1449 mL |
16.4312 mL |
| 10 mM |
0.3286 mL |
1.6431 mL |
3.2862 mL |
6.5725 mL |
8.2156 mL |
| 50 mM |
0.0657 mL |
0.3286 mL |
0.6572 mL |
1.3145 mL |
1.6431 mL |
| 100 mM |
0.0329 mL |
0.1643 mL |
0.3286 mL |
0.6572 mL |
0.8216 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Yao Xue Xue Bao. 1989;24(3):200-6. | | Studies on the structures of new flavonoids from the root of Scutellaria amoena.[Pubmed: 2816376] |
From the root of Scutellaria amoena C.H. Wright, two new flavonoids (I, II) and six known flavonoids (III-VIII) were isolated.
METHODS AND RESULTS:
On the basis of spectroscopic analysis (UV, 1HNMR, 13CNMR, MS and CD) and chemical evidences, the structures of I and II were elucidated as (2S)-2',5,6'-trihydroxy-7-methoxyflavanone-2'-O-beta-D-glucopyrano side (I) and (2R, 3R)-2',3,5,7-tetrahydroxyflavanone (II) respectively. The other six known compounds were identified as (2S)-5,7,8-trihydroxyflavanone (III), (2S)-2',5,6',7-tetrahydroxyflavanone (IV), (2R, 3R)-2',3,5,6',7-Pentahydroxyflavanone (V), 2',5,6',7-tetrahydroxyflavone (VI) norwogonin (VII) and oroxylin-A (VIII) respectively.
CONCLUSIONS:
Compounds III-VIII were obtained from this plant for the first time. |
|
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