| In vivo: |
| Planta Med. 2011 Sep;77(14):1569-74. | | The 2',4',6'-trihydroxyacetophenone isolated from Myrcia multiflora has antiobesity and mixed hypolipidemic effects with the reduction of lipid intestinal absorption.[Pubmed: 21472649] | This study evaluated the hypolipidemic and antiobesity effects of phloroacetophenone (2',4',6'-Trihydroxyacetophenone, THA) isolated from Myrcia multiflora and their relationship with triglyceride (TG) intestinal absorption and pancreatic lipase activity inhibition.
METHODS AND RESULTS:
The hypolipidemic effect of 2',4',6'-Trihydroxyacetophenone was evaluated by acute (Triton WR-1339 treatment) and chronic assay (high-fat diet treatment), the antiobesity effect was evaluated by chronic assay (high-fat diet treatment), while the inhibition of enzymatic activity of pancreatic lipase was measured in the intestinal tissue of mice treated with high olive oil concentration. In the acute assay, 2',4',6'-Trihydroxyacetophenone caused greater total cholesterol (37 %) and triglyceride (46 %) serum level reduction than lovastatin (32 and 1 %), a HMG-CoA reductase inhibitor or orlistat (26 and 34 %), a gastrointestinal lipase inhibitor. In addition, in the chronic assay with a high-fat diet, 2',4',6'-Trihydroxyacetophenone reduced cholesterol and triglyceride levels (32 and 61 %, respectively) while lovastatin showed a decrease of 35 and 49 %, respectively. 2',4',6'-Trihydroxyacetophenone also caused a reduction in weight gain very similar to orlistat (40 and 38 %, respectively) when the animals were submitted to a high-fat diet. Moreover, 2',4',6'-Trihydroxyacetophenone showed a stronger and continuous pancreatic lipase inhibitory activity when compared with orlistat, causing inhibition of this enzyme during 6 hours associated to a significant reduction of triglyceride serum levels.
CONCLUSIONS:
The IN VIVO antiobesity and hypolipidemic effects of 2',4',6'-Trihydroxyacetophenone may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity. |
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