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2',4'-Dihydroxydihydrochalcone
2',4'-Dihydroxydihydrochalcone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2',4'-Dihydroxydihydrochalcone
Price: $318 / 20mg
CAS No.: 53596-71-7
Catalog No.: CFN70401
Molecular Formula: C15H14O3
Molecular Weight: 242.3 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The resins of Dracaena draco.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $94.0 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 2',4'-Dihydroxydihydrochalcone has cytotoxic, and anti-inflammatory activities.
In vitro:
Natural product communications, 2013, 8(9):1255-1256.
Cytotoxic activity of dihydrochalcones isolated from Corema album leaves against HT-29 colon cancer cells.[Reference: WebLink]

METHODS AND RESULTS:
During our search for cytotoxic compounds from Andalusian vascular plants, the ethyl acetate extract from the leaves of Corema album (L.) D. Don (Ericaceae) was selected for its cytotoxic activity against the HT-29 human colon adenocarcinoma cell line. Two dihydrochalcones, 2',4'-Dihydroxydihydrochalcone (1) and 2'-methoxy-4'-hydroxydihydrochalcone (2), have been isolated from the leaves of C. album. Their structural identification was based on 1H NMR and 13C NMR data, including 2D NMR, and mass spectrometry. These compounds were subjected to the sulfhorhodamine B (SRB) cytotoxic assay against human colon adenocarcinoma cells (HT-29).
CONCLUSIONS:
Compounds 1 and 2 showed higher cytotoxicity than the positive control 5-fluorouracil (5-FU); the IC50 values (microM +/- SEM) were 1.8 +/- 0.4 for compound 1, 8.5 +/- 2.1 microM for compound 2, and 8.7 +/- 4.0 for 5-FU. The cytotoxic activity of 1 and 2 was reduced in the presence of the antioxidants N-acetylcysteine (NAC) and Mn(III) Tetrakis(1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP), therefore suggesting that reactive oxygen species generation participates in the cytotoxic activity of these dihydrochalcones.
In vivo:
Planta medica, 2008, 74(3):312-313.
Investigation on Anti-inflammatory Effect and Chemical Constituents of Total Flavonoid Aglycones from Tibetan Medicine Oxytropisfalcata.[Reference: WebLink]
Oxytropis falcata is a wild growing Leguminosae plant which distributes Qinghai-Tibet Plateau in China. The herb of this plant has been known as one of “Three Anti-inflammatory Drugs” in Chinese Tibetan medicine, and used to treat inflammation and nociception for thousands years[1,2].
METHODS AND RESULTS:
In order to make the active material foundation corresponding to its anti-inflammatory effect clear, several main ingredients including essential oil, alkaloids, flavonoid aglycones and saponins were isolated, respectively, and then anti-inflammatory effect was evaluated and compared by TPA-induced ear oedema and carrageenan-induced peritonitis in mice. Subsequently, column chromatographic method was used to separate chemical constituents from the most active anti-inflammatory ingredient, whose structures were elucidated by NMR spectral data and physical and chemical properties. Oral administration of total flavonoid aglycones (1200 mg dry raw material/kg) could significantly (p < 0.01, compare to vehicle) inhibit the ear oedema induced by TPA and peritoneal leukocyte migration in mice at a rate of 61.1% and 56.4%, and indomethacin (10 mg/kg) showed 58.6% and 60.1% inhibition, respectively. Furthermore, pinostrobin, pinocembrin, 7-hydroxy flavonone, liquiritigenin, 2',4'-Dihydroxydihydrochalcone, 2ʹ,4ʹ-dihydroxy chalcone, 2ʹ-methoxy-4ʹ-hydroxy chalcone, 2ʹ-hydroxy-4ʹ-methoxy chalcone, 2ʹ,4-dihydroxy-4ʹ-methoxy chalcone, isoliquiritigenin, 3ʹ,7-dihydroxy-2ʹ,4ʹ-dimethoxy isoflavane, genistein, Ψ-baptigenin, formononetin, 7-hydroxy flavone, kaempferol, isorhamnetin, quercetin, myricetin, chrysin, apigenin, luteolin were isolated and elucidated from active ingredient.
CONCLUSIONS:
The results suggested that the total flavonoid aglycones possess most strong anti-inflammatory activity of main ingredients from Oxytropis falcata, and 12 flavonoids were isolated from which for the first time.
2',4'-Dihydroxydihydrochalcone Description
Source: The resins of Dracaena draco.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
China Journal of Chinese Materia Medica, 2008, 33(22):2639.
Studies on chemical constituents of Tibetan medicine Caryopteris toroetii.[Reference: WebLink]
To study the chemical constituents of the Tibetan medicine Caryopteris toroetii.
METHODS AND RESULTS:
The crude drug was extracted with 95% EtOH and isolated by repeatedly chromatographic methods.
CONCLUSIONS:
The structures of the isolated compounds were elucidated by spectral analysis. Six compounds were yielded and identified as: phenethyl cinnamide (1), 1-hydroxy-2, 3, 4, 5-tetramethoxy-xanthone (2), 1-hydroxy-2, 3, 5-trimethoxy-xanthone (3), (2S)-5-hydroxy-7-methoxyflavanone (4), 2',4'-Dihydroxydihydrochalcone(5) and rutin (6). All the above compounds were obtained from C. toroetii for the first time.
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