Jatrophane 5 | CAS:210108-89-7 | Manufacturer ChemFaces

Jatrophane 5

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Description:

Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

Targets:

P-gp

In vitro:

Phytochemistry. 2013 Feb;86:208-17.

Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.[Pubmed: 23079764]

METHODS AND RESULTS:
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed.
CONCLUSIONS:
Jatrophane 2 and Jatrophane 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

Jatrophane 5 Description

Source:	The branches of Jatropha carcas L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Jatrophane 5
Price:
CAS No.:	210108-89-7
Catalog No.:	CFN98055
Molecular Formula:	C₄₁H₄₉NO₁₄
Molecular Weight:	779.8 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The branches of Jatropha carcas L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Diterpenoids Compound Library P-gp Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2824 mL	6.4119 mL	12.8238 mL	25.6476 mL	32.0595 mL
5 mM	0.2565 mL	1.2824 mL	2.5648 mL	5.1295 mL	6.4119 mL
10 mM	0.1282 mL	0.6412 mL	1.2824 mL	2.5648 mL	3.206 mL
50 mM	0.0256 mL	0.1282 mL	0.2565 mL	0.513 mL	0.6412 mL
100 mM	0.0128 mL	0.0641 mL	0.1282 mL	0.2565 mL	0.3206 mL

CFN98054	Jatrophane 4	210108-88-6	744.8	C₃₉H₅₂O₁₄
CFN98052	Jatrophane 2	210108-86-4	758.8	C₃₉H₅₀O₁₅
CFN98055	Jatrophane 5	210108-89-7	779.8	C₄₁H₄₉NO₁₄
CFN98053	Jatrophane 3	210108-87-5	807.9	C₄₃H₅₃NO₁₄
CFN97144	Pepluanin A	670257-89-3	821.9	C₄₃H₅₁NO₁₅
CFN92863	Kansuinine A	57701-86-7	730.8	C₃₇H₄₆O₁₅
CFN92866	Kansuinine B	57685-46-8	722.7	C₃₈H₄₂O₁₄
CFN92869	Kansuinine E	672945-84-5	777.8	C₄₁H₄₇NO₁₄
CFN89380	Jatrophane I	210108-85-3	699.74	C₃₆H₄₅NO₁₃
CFN89381	Jatrophane VI	210108-90-0	716.76	C₃₇H₄₈O₁₄