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Jatrophane 2
Jatrophane 2
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Jatrophane 2
Price:
CAS No.: 210108-86-4
Catalog No.: CFN98052
Molecular Formula: C39H50O15
Molecular Weight: 758.8 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The branches of Jatropha carcas L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Jatrophane 2 also demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Targets: Antifection | P-gp
In vitro:
Phytochemistry. 2013 Feb;86:208-17.
Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.[Pubmed: 23079764 ]

METHODS AND RESULTS:
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed.
CONCLUSIONS:
Jatrophane 2 and Jatrophane 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Jatrophane 2 Description
Source: The branches of Jatropha carcas L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3179 mL 6.5894 mL 13.1787 mL 26.3574 mL 32.9468 mL
5 mM 0.2636 mL 1.3179 mL 2.6357 mL 5.2715 mL 6.5894 mL
10 mM 0.1318 mL 0.6589 mL 1.3179 mL 2.6357 mL 3.2947 mL
50 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.5271 mL 0.6589 mL
100 mM 0.0132 mL 0.0659 mL 0.1318 mL 0.2636 mL 0.3295 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Journal of Natural Medicines,2010,8(2) :81-8
A new jatrophane diterpenoid from Euphorbia peplus.[Reference: WebLink]
To study the chemical constituents of Euphorbia peplus.
METHODS AND RESULTS:
Compounds 1-3 were isolated and purified by silica gel column chromatography,MCI and Sephadex LH-20.Their structures were mainly elucidated by spectroscopic analysis and physicochemical characteristics.Three compounds were identified as euphopeplin A(1),2α,5α,7β,8α,9α, 14β-hexaacetoxy-3β-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene(Jatrophane 2,2)and 5α,8α,9β,10β,14α-pentaacetoxy-3β-benzoy-loxy-15-hydroxypepluane(3).
CONCLUSIONS:
A new jatrophane diterpenoid,euphopeplin A(1)was isolated from Euphorbia peplus.
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