Science | Nature | Cell | View More
Natural Products
21-Episerratenediol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 21-Episerratenediol
Price:
CAS No.: 1449-06-5
Catalog No.: CFN99495
Molecular Formula: C30H50O2
Molecular Weight: 442.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Lycopodium serratum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad Veracuzana (Mexico)
  • Universidade do Porto (Portugal)
  • University of Leipzig (Germany)
  • University of Stirling (United Kingdom)
  • Michigan State University (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Regional Crop Research Institute (Korea)
  • The Australian National University (Australia)
  • University of Malaya (Malaysia)
  • University of Cincinnati (USA)
  • University of Wuerzburg (Germany)
  • More...
Package
Featured Products
Rosmarinyl glucoside

Catalog No: CFN95297
CAS No: 910028-78-3
Price: $413/5mg
Ganodermanondiol

Catalog No: CFN99085
CAS No: 107900-76-5
Price: $318/5mg
Asperosaponin VI

Catalog No: CFN99766
CAS No: 39524-08-8
Price: $30/20mg
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Alisol B

Catalog No: CFN92406
CAS No: 18649-93-9
Price: $118/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg
trans-4-Hydroxycinnamic acid

Catalog No: CFN98794
CAS No: 501-98-4
Price: $30/20mg
Paclitaxel

Catalog No: CFN97759
CAS No: 33069-62-4
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 21-Episerratenediol may be as a potent cancer chemopreventive agent.
In vitro:
Cancer Lett. 2003 Jul 10;196(2):121-6.
Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.[Pubmed: 12860269]

METHODS AND RESULTS:
Eleven serratane-type triterpenoids isolated from the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. hondoensis (Mayer) Rehder (Pinaceae) and three synthetic analogs were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 21-Episerratenediol, serratenediol, diepiserratenediol, 3 beta-hydroxyserrat-14-en-21-one, 3 alpha-methoxy-21 beta-hydroxyserrat-14-en-16-one, 3 beta-methoxyserrat-14-en-21 beta-yl acetate, 3 alpha-methoxyserrat-14-en-21 beta-yl acetate and 3 beta-methoxyserrat-14-en-21 alpha-yl acetate demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity, their effects being stronger than that of a representative control, oleanolic acid. Furthermore, 21-Episerratenediol exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
CONCLUSIONS:
The result of the present investigation indicated that 21-Episerratenediol might be valuable as a potent cancer chemopreventive agent.
Cancer Lett. 2004 Oct 28;214(2):149-56.
Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.[Pubmed: 15363540]
3beta-Methoxyserrat-14-en-21beta-ol (1) and 3alpha-methoxyserrat-14-en-21beta-ol (2) are the most abundant triterpenoids from two Picea plants, Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis and P. jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayr) Rehder, and the total yield of 1 and 2 reach over 1/3 of the chloroform extract of the above two plants.
METHODS AND RESULTS:
This study deals with the potential of anti-tumor promoting activity of 1 and results of the assay of 22 synthetic serratane-type triterpenoids (6)-(27) derived from 1, 2, 21-Episerratenediol (3), diepiserratenediol (4) and 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (5) to discuss the structure-activity relationship. As a preliminary evaluation of their potential to inhibit tumor promotion, the inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) were used. All compounds except for 12 and 19 showed potent inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA), their effects being stronger than that of a positive control oleanolic acid. Compounds 1, 13, 14, 18, 20 and 26 were selected to examine the effect on the in vivo two-stage mouse skin carcinogenesis test induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
CONCLUSIONS:
The most abundant triterpenoid 1 and the synthetic compounds 13 and 14 were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test, and compounds 18, 20 and 26 also showed strong inhibitory effects.
21-Episerratenediol Description
Source: The herbs of Lycopodium serratum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
(R)-5,3'-Dimethyl hesperidin

Catalog No: CFN95310
CAS No: N/A
Price: $318/5mg
Gynosaponin TN2

Catalog No: CFN95331
CAS No: 77658-95-8
Price: $318/5mg
Macrophylloside D

Catalog No: CFN95113
CAS No: 179457-69-3
Price: $318/10mg
Selaginellin

Catalog No: CFN95030
CAS No: 941269-84-7
Price: $338/5mg
Arjunglucoside I

Catalog No: CFN95049
CAS No: 62319-70-4
Price: $268/10mg
Geoside

Catalog No: CFN95233
CAS No: 585-90-0
Price: $368/5mg
Murracarpin

Catalog No: CFN95409
CAS No: 120786-76-7
Price: $413/5mg
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2589 mL 11.2943 mL 22.5887 mL 45.1773 mL 56.4717 mL
5 mM 0.4518 mL 2.2589 mL 4.5177 mL 9.0355 mL 11.2943 mL
10 mM 0.2259 mL 1.1294 mL 2.2589 mL 4.5177 mL 5.6472 mL
50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Rosmarinyl glucoside

Catalog No: CFN95297
CAS No: 910028-78-3
Price: $413/5mg
Ganodermanondiol

Catalog No: CFN99085
CAS No: 107900-76-5
Price: $318/5mg
Asperosaponin VI

Catalog No: CFN99766
CAS No: 39524-08-8
Price: $30/20mg
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Alisol B

Catalog No: CFN92406
CAS No: 18649-93-9
Price: $118/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Sugiol

Catalog No: CFN92187
CAS No: 511-05-7
Price: $ / mg
Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg
trans-4-Hydroxycinnamic acid

Catalog No: CFN98794
CAS No: 501-98-4
Price: $30/20mg
Paclitaxel

Catalog No: CFN97759
CAS No: 33069-62-4
Price: $30/20mg
Tags: buy 21-Episerratenediol | 21-Episerratenediol supplier | purchase 21-Episerratenediol | 21-Episerratenediol cost | 21-Episerratenediol manufacturer | order 21-Episerratenediol | 21-Episerratenediol distributor