(2R)-5,7-Dimethoxyflavanone | CAS:1277188-85-8

(2R)-5,7-Dimethoxyflavanone

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Description:

5,7-Dimethoxyflavanone has anti-inflammatory activity.

Targets:

TNF-α | IL Receptor | NO | IFN-γ

In vitro:

J Ethnopharmacol. 2005 Sep 14;100(3):249-53.

Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima.[Pubmed: 15893896]

The anti-inflammatory activities of five flavonoids, namely 5,7-dimethoxyflavanone (1), 5,7-dimethoxy-3',4'-methylenedioxyflavanone (2), isobonducellin (3), 2'-hydroxy-2,3,4',6'-tetramethoxychalcone (4) and bonducellin (5), all of them isolated from Caesalpinia pulcherrima L. was studied in lipopolysaccharide (LPS) and interferon (IFN)-gamma activated murine peritoneal macrophages.
METHODS AND RESULTS:
These five compounds significantly and dose-dependently inhibited the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. According to their inhibitory results, the order of anti-inflammatory potency was compounds 3>5>4>2>1. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-gamma for 24h, and determined the inhibitory effects of the above-mentioned isolates on the production of NO after a further 24h.
CONCLUSIONS:
The present study supports the use of Caesalpinia pulcherrima for the treatment of inflammatory diseases in traditional medicine. This is the first study on compounds 1-5 about their anti-inflammatory activities.

(2R)-5,7-Dimethoxyflavanone Description

Source:	The black rhizomes of Boesenbergia panduta.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(2R)-5,7-Dimethoxyflavanone
Price:	$413 / 5mg
CAS No.:	1277188-85-8
Catalog No.:	CFN90899
Molecular Formula:	C₁₇H₁₆O₄
Molecular Weight:	284.31 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The black rhizomes of Boesenbergia panduta.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Flavonoids Compound Library TNF-α Inhibitor Library NO Inhibitor Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL	70.3457 mL	87.9322 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL	14.0691 mL	17.5864 mL
10 mM	0.3517 mL	1.7586 mL	3.5173 mL	7.0346 mL	8.7932 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.4069 mL	1.7586 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8793 mL

CFN92422	Onysilin	73695-94-0	300.3	C₁₇H₁₆O₅
CFN99241	5-Hydroxy-7,8-dimethoxyflavanone	113981-49-0	300.3	C₁₇H₁₆O₅
CFN98910	7-Hydroxy-5,8-dimethoxyflavanone	54377-24-1	300.3	C₁₇H₁₆O₅
CFN95580	8-Hydroxy-5,7-dimethoxyflavanone	201230-40-2	300.3	C₁₇H₁₆O₅
CFN97739	Isopedicin	4431-42-9	330.34	C₁₈H₁₈O₆
CFN94487	7-Hydroxyflavanone	6515-36-2	240.26	C₁₅H₁₂O₃
CFN98740	Pinocembrin	480-39-7	256.3	C₁₅H₁₂O₄
CFN99096	Pinocembrin 7-acetate	109592-60-1	298.3	C₁₇H₁₄O₅
CFN99211	Pinocembrin diacetate	111441-88-4	340.3	C₁₉H₁₆O₆
CFN98739	Pinostrobin	480-37-5	270.3	C₁₆H₁₄O₄