3,9-Dihydroeucomin | CAS:887375-68-0 | Manufacturer ChemFaces

3,9-Dihydroeucomin

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Description:

(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.

Targets:

IL Receptor | IFN-γ

In vitro:

Molecules. 2009 May 12;14(5):1789-95.

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine ex Engelm.[Pubmed: 19471199 ]

Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm.
METHODS AND RESULTS:
Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by (3)H-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC(50) values 19.4, 73.8, and 58.8 microM, respectively.
CONCLUSIONS:
All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

3,9-Dihydroeucomin Description

Source:	The leaves of Agave sisalana Perrine ex Engelm.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3,9-Dihydroeucomin
Price:
CAS No.:	887375-68-0
Catalog No.:	CFN96519
Molecular Formula:	C₁₇H₁₆O₅
Molecular Weight:	300.31 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The leaves of Agave sisalana Perrine ex Engelm.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Immunomodulators Compound Library Flavonoids Compound Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3299 mL	16.6495 mL	33.2989 mL	66.5978 mL	83.2473 mL
5 mM	0.666 mL	3.3299 mL	6.6598 mL	13.3196 mL	16.6495 mL
10 mM	0.333 mL	1.6649 mL	3.3299 mL	6.6598 mL	8.3247 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.6649 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL

CFN91153	Loureiriol	479195-44-3	302.3	C₁₆H₁₄O₆
CFN96506	Eucomol	17934-12-2	316.31	C₁₇H₁₆O₆
CFN96517	7-O-Methyleucomol	17934-15-5	330.33	C₁₈H₁₈O₆
CFN99081	3'-Hydroxy-3,9-dihydroeucomin	107585-75-1	316.3	C₁₇H₁₆O₆
CFN97500	8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin	93078-83-2	316.3	C₁₇H₁₆O₆
CFN91154	(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one	84638-48-2	300.3	C₁₇H₁₆O₅
CFN96337	Ophiopogonanone A	75239-63-3	328.3	C₁₈H₁₆O₆
CFN96342	3-(2,4-Dihydroxybenzyl)-5-hydroxy-7,8-dimethoxy-6-methylchroman-4-one	149180-48-3	360.4	C₁₉H₂₀O₇
CFN96332	Ophiopogonanone E	588706-66-5	360.4	C₁₉H₂₀O₇
CFN96338	Ophiopogonanone F	588706-67-6	374.4	C₂₀H₂₂O₇