3-Epiursolic acid | CAS:989-30-0 | Manufacturer ChemFaces

3-Epiursolic acid

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Size /Price /Stock	10 mM * 1 mL in DMSO / $113.2 / In-stock
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Description:

3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 uM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents.

Targets:

Immunology & Inflammation related

In vitro:

Phytother Res. 2000 Sep;14(6):463-5.

Antiinflammatory activity and chemical composition of extracts of Verbena officinalis.[Pubmed: 10960904]

In an attempt to locate the biologically active fraction(s) of the plant Verbena officinalis Linn. (Verbenaceae), a preliminary screening of successive petroleum ether, chloroform and methanol extracts of aerial parts for antiinflammatory activity using carrageenan paw oedema model was carried out.
METHODS AND RESULTS:
All three extracts were found to exhibit antiinflammatory activity with the chloroform extract being the most active. Chemical investigations of petroleum ether and chloroform extracts led to the isolation of beta-sitosterol, ursolic acid, oleanolic acid, 3-Epiursolic acid, 3-epioleanolic acid, and minor triterpenoids of derivatives of ursolic acid and oleanolic acids. Chromatographic purification of the methanol extract yielded two iridoid glucosides, verbenalin and hastatoside, a phenylpropanoid glycoside, verbascoside and beta-sitosterol-D-glucoside.

3-Epiursolic acid Description

Source:	The leaves of Eriobotrya japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Chem Biodivers. 2014 Sep;11(9):1354-63.

Triterpenoids as novel natural inhibitors of human cathepsin L.[Pubmed: 25238076 ]

Cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents.
METHODS AND RESULTS:
Using a bioactivity-guided fractionation, a series of triterpenoids was identified as a new class of competitive inhibitors towards cathepsin L with affinity values in micromolar range. Among the 14 compounds evaluated, the most promising were 3-Epiursolic acid (3), 3-(hydroxyimino)oleanolic acid (9), and 3-(hydroxyimino)masticadienoic acid (13) with IC50 values of 6.5, 2.4, and 2.6 μM on catL, respectively. Most of the evaluated triterpenoids do not inhibit cathepsin B.
CONCLUSIONS:
Thus, the evaluated compounds exhibit a great potential to help in the design of new inhibitors with enhanced potency and affinity towards catL. Docking studies were performed in order to gain insight on the binding mode and SAR of these compounds.

Product Name	3-Epiursolic acid
Price:	$388 / 20mg
CAS No.:	989-30-0
Catalog No.:	CFN92196
Molecular Formula:	C₃₀H₄₈O₃
Molecular Weight:	456.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The leaves of Eriobotrya japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Inhibitors Compound Library Triterpenoids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	43.7924 mL	54.7405 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	8.7585 mL	10.9481 mL
10 mM	0.219 mL	1.0948 mL	2.1896 mL	4.3792 mL	5.4741 mL
50 mM	0.0438 mL	0.219 mL	0.4379 mL	0.8758 mL	1.0948 mL
100 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4379 mL	0.5474 mL

CFN97219	Acetylursolic acid	7372-30-7	498.8	C₃₂H₅₀O₄
CFN97078	Ursonic acid	6246-46-4	454.7	C₃₀H₄₆O₃
CFN91138	Randialic acid B	14021-14-8	454.7	C₃₀H₄₆O₃
CFN91139	Sanguisorbigenin	6812-98-2	454.7	C₃₀H₄₆O₃
CFN90556	Obtusilin	105870-59-5	470.69	C₃₀H₄₆O₄
CFN97281	Rubifolic acid	80489-65-2	472.7	C₃₀H₄₈O₄
CFN98292	Zamanic acid	260393-05-3	618.9	C₃₉H₅₄O₆
CFN98486	3-Hydroxy-11-ursen-28,13-olide	35959-05-8	454.7	C₃₀H₄₆O₃
CFN98487	3-Acetoxy-11-ursen-28,13-olide	35959-08-1	496.7	C₃₂H₄₈O₄
CFN99623	Tereticornate A	149751-81-5	630.9	C₄₀H₅₄O₆