Science | Nature | Cell | View More
Natural Products
3'-Methoxypuerarin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 3'-Methoxypuerarin
Price: $158 / 20mg
CAS No.: 117047-07-1
Catalog No.: CFN90780
Molecular Formula: C22H22O10
Molecular Weight: 446.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Pueraria lobata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $42.3 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Toulouse (France)
  • Aveiro University (Portugal)
  • Monash University Malaysia (Malaysia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Kyoto University (Japan)
  • University of Wollongong (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Korea Intitute of Science and T... (Korea)
  • Yale University (USA)
  • University of Vigo (Spain)
  • Donald Danforth Plant Science C... (USA)
  • More...
Package
Featured Products
Tetramethylpyrazine

Catalog No: CFN99909
CAS No: 1124-11-4
Price: $30/20mg
Kirenol

Catalog No: CFN98867
CAS No: 52659-56-0
Price: $50/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Petunidin-3-O-galactoside chloride

Catalog No: CFN92042
CAS No: 28500-02-9
Price: $318/5mg
Stigmasterol

Catalog No: CFN97326
CAS No: 83-48-7
Price: $30/20mg
Carnosic acid

Catalog No: CFN99102
CAS No: 3650-09-7
Price: $40/20mg
Ginsenoside Rc

Catalog No: CFN99973
CAS No: 11021-14-0
Price: $70/20mg
Procyanidin B2

Catalog No: CFN99558
CAS No: 29106-49-8
Price: $138/20mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 3'-Methoxypuerarin shows neuron protection activity, it can protect hippocampal neurons against ischemia/reperfusion injury by inhibiting apoptosis. 3'-Methoxypuerarin has antioxidant activities, it shows ONOO(-) scavenging activity and weak NO· and O(2)(-) scavenging activities.
Targets: NO | ROS
In vitro:
Arch. Pharm. Res., 2012, 35(5):823-37.
Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots.[Pubmed: 22644850 ]
In order to evaluate the anti-inflammatory and antioxidant activities of Pueraria lobata roots and its active components, in vitro inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein expression, and tert-butylhydroperoxide (t-BHP)-induced reactive oxygen species (ROS) generation in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)), nitric oxide (NO·), superoxide anion (·O(2)(-)) and total ROS, and inhibitory activities against ONOO(-)-mediated tyrosine nitration, were determined.
METHODS AND RESULTS:
Repeated column chromatography was performed to isolate four known compounds from the anti-inflammatory and antioxidant EtOAc fraction: daidzein; genistein; puerarin; (+)-puerarol B-2-O-glucopyranoside; four known compounds from the anti-inflammatory n-hexane fraction: lupenone; lupeol; puerarol; coumestrol; seven known compounds from the antioxidant n-BuOH fraction: allantoin; 3'-hydroxypuerarin; daidzein 8-C-apiosyl-(1→6)-glucoside; puerarin; genistin; 3'-Methoxypuerarin; daidzin. Among these compounds, lupenone and lupeol reduced NO production, as well as iNOS and COX-2 protein levels in LPS-stimulated RAW 264.7 cells. Furthermore, lupeol showed significant inhibitory activity against intracellular ROS generation by t-BHP. Meanwhile, 3'-hydroxypuerarin showed marked ONOO(-), NO·, total ROS scavenging activities, and weak ·O(2)(-) scavenging activity, while 3'-Methoxypuerarin showed ONOO(-) scavenging activity and weak NO· and O(2)(-) scavenging activities, suggesting that existence of the 3'-hydroxyl group in puerarin plays an important role in the scavenging of ONOO(-), NO·, and total ROS, as well as inhibiting the ONOO(-)-mediated tyrosine nitration mechanism.
CONCLUSIONS:
These results indicate that P. lobata roots and its constituents may be a useful therapeutic and preventive approach to various inflammatory diseases and oxidative stress-related disease.
In vivo:
Chinese Journal of Physiology, 2010, 53(2):136-40.
Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury.[Pubmed: 21793321]
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae. The aim of this study was to investigate the role and the mechanism of 3'-MOP in the protection of hippocampal neurons against cerebral ischemia/reperfusion (I/R) injury in rats.
METHODS AND RESULTS:
I/R injury was induced by a modified four-vessel occlusion model. Rats were randomly divided into an I/R group, an I/R + 3'-MOP group and a control group. Histological changes in the neurons of the hippocampal CA1 region were observed with hematoxylin and eosine (H&E) staining. The apoptotic neurons in the hippocampal CA1 area were counted with the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining.
CONCLUSIONS:
The results showed that compared with the I/R group, 3'-MOP increased the number of surviving neurons in the hippocampal CA1 region (P < 0.001) and markedly reduced the number of apoptotic pyramidal neurons (P < 0.001) after I/R injury. In conclusion, 3'-MOP can protect hippocampal neurons against I/R injury by inhibiting apoptosis.
3'-Methoxypuerarin Description
Source: The roots of Pueraria lobata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
20-O-Glucoginsenoside Rf

Catalog No: CFN95036
CAS No: 68406-27-9
Price: $318/5mg
6''-O-Acetylsaikosaponin D

Catalog No: CFN95090
CAS No: 64340-45-0
Price: $288/5mg
Nortrachelogenin-5'-C-beta-glucosi...

Catalog No: CFN95251
CAS No: 858127-39-6
Price: $318/10mg
Platycogenin A

Catalog No: CFN95240
CAS No: 1459719-53-9
Price: $388/5mg
Resinacein D

Catalog No: CFN95591
CAS No: 2231061-47-3
Price: $413/5mg
11-Deoxyisomogroside V

Catalog No: CFN95288
CAS No: 1628293-32-2
Price: $368/10mg
New compound 14

Catalog No: CFN95381
CAS No: N/A
Price: $413/5mg
3''-Galloylquercitrin

Catalog No: CFN95048
CAS No: 503446-90-0
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2401 mL 11.2007 mL 22.4014 mL 44.8029 mL 56.0036 mL
5 mM 0.448 mL 2.2401 mL 4.4803 mL 8.9606 mL 11.2007 mL
10 mM 0.224 mL 1.1201 mL 2.2401 mL 4.4803 mL 5.6004 mL
50 mM 0.0448 mL 0.224 mL 0.448 mL 0.8961 mL 1.1201 mL
100 mM 0.0224 mL 0.112 mL 0.224 mL 0.448 mL 0.56 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Tetramethylpyrazine

Catalog No: CFN99909
CAS No: 1124-11-4
Price: $30/20mg
Kirenol

Catalog No: CFN98867
CAS No: 52659-56-0
Price: $50/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
3-oxo-Olean-12-en-28-oic acid

Catalog No: CFN92194
CAS No: 17990-42-0
Price: $90/20mg
Petunidin-3-O-galactoside chloride

Catalog No: CFN92042
CAS No: 28500-02-9
Price: $318/5mg
Stigmasterol

Catalog No: CFN97326
CAS No: 83-48-7
Price: $30/20mg
Carnosic acid

Catalog No: CFN99102
CAS No: 3650-09-7
Price: $40/20mg
Ginsenoside Rc

Catalog No: CFN99973
CAS No: 11021-14-0
Price: $70/20mg
Procyanidin B2

Catalog No: CFN99558
CAS No: 29106-49-8
Price: $138/20mg
Astragaloside III

Catalog No: CFN99174
CAS No: 84687-42-3
Price: $268/20mg
Tags: buy 3'-Methoxypuerarin | 3'-Methoxypuerarin supplier | purchase 3'-Methoxypuerarin | 3'-Methoxypuerarin cost | 3'-Methoxypuerarin manufacturer | order 3'-Methoxypuerarin | 3'-Methoxypuerarin distributor