4'-Hydroxy-2,4-dimethoxychalcone | CAS:151135-64-7

4'-Hydroxy-2,4-dimethoxychalcone

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Description:

4'-Hydroxy-2,4-dimethoxychalcone has antimalarial activity.

In vivo:

Pharmacology. 2011;87(1-2):96-104.

In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones.[Pubmed: 21282967]

METHODS AND RESULTS:
4'-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/dose, daily for 5 days. In contrast, we found that oral dosing of MBC at 640 mg/kg/dose, daily for 5 days, failed to extend the survivability of P. berghei-infected mice. The timing of compound administration and metabolic activation likely contribute to the outcome of efficacy testing in vivo. Microsomal digest of MBC yielded 4'-n-butoxy-4-hydroxy-2-methoxy-chalcone and 4'-(1-hydroxy-n-butoxy)-2,4-dimethoxy-chalcone.
CONCLUSIONS:
We propose that the latter will hydrolyze in vivo to 4'-Hydroxy-2,4-dimethoxychalcone, which has greater efficacy than MBC in our P. berghei-infected mouse model and was detected in plasma following oral dosing of mice with MBC. Pharmacokinetic parameters suggest that poor absorption, distribution, metabolism and excretion properties contribute to the limited in vivo efficacy observed for MBC and its analogs.

4'-Hydroxy-2,4-dimethoxychalcone Description

Source:	The herbs of Bauhinia glauca
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	4'-Hydroxy-2,4-dimethoxychalcone
Price:	$338 / 10mg
CAS No.:	151135-64-7
Catalog No.:	CFN91163
Molecular Formula:	C₁₇H₁₆O₄
Molecular Weight:	284.3 g/mol
Purity:	>=98%
Type of Compound:	Chalcones
Physical Desc.:	Powder
Source:	The herbs of Bauhinia glauca
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Chalcones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5174 mL	17.5871 mL	35.1741 mL	70.3482 mL	87.9353 mL
5 mM	0.7035 mL	3.5174 mL	7.0348 mL	14.0696 mL	17.5871 mL
10 mM	0.3517 mL	1.7587 mL	3.5174 mL	7.0348 mL	8.7935 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.407 mL	1.7587 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8794 mL

CFN70089	2-Benzal-4-hydroxyacetophenone	2657-25-2	224.2	C₁₅H₁₂O₂
CFN95493	2',4'-Dihydroxychalcone	1776-30-3	240.3	C₁₅H₁₂O₃
CFN70481	3,4-Dimethoxychalcone	5416-71-7	268.3	C₁₇H₁₆O₃
CFN98776	Butein	487-52-5	272.3	C₁₅H₁₂O₅
CFN70340	Homobutein	34000-39-0	286.3	C₁₆H₁₄O₅
CFN96387	4-O-Methylbutein	13323-67-6	286.3	C₁₆H₁₄O₅
CFN91535	Calythropsin	152340-67-5	286.3	C₁₆H₁₄O₅
CFN91415	Dihydrocalythropsin	151703-05-8	288.3	C₁₆H₁₆O₅
CFN89465	3,2'-Dihydroxy-4,4'-dimethoxychalcone	2567-65-9	300.30	C₁₇H₁₆O₅
CFN91425	2',4-Dihydroxy-3,4',6'-trimethoxychalcone	1776-29-0	330.3	C₁₈H₁₈O₆