4-O-Methylepisappanol | CAS:112529-37-0

4-O-Methylepisappanol

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Description:

4-O-Methylepisappanol shows moderate neuroprotective effect at 40 microM.

Targets:

HO-1

In vitro:

Biol Pharm Bull. 2009 May;32(5):945-9.

Cytoprotective constituents of the heartwood of Caesalpinia sappan on glutamate-induced oxidative damage in HT22 cells.[Pubmed: 19420770]

METHODS AND RESULTS:
The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-Methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2'-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpine J (5), pluchoic acid (6).
CONCLUSIONS:
At concentrations of 20-40 microM, compound 2 showed significant cytoprotective effects against glutamate-induced oxidative stress through the induction of heme oxygenase (HO)-1 in HT22-immortalized hippocampal cells. Compound 3 also showed moderate neuroprotective effect at 40 microM, but compounds 1, 4-6 did not show any protective effects against glutamate-induced cytotoxicity in HT22 cells.

4-O-Methylepisappanol Description

Source:	The roots of Caesalpinia decapetala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	4-O-Methylepisappanol
Price:
CAS No.:	112529-37-0
Catalog No.:	CFN92769
Molecular Formula:	C₁₇H₁₈O₆
Molecular Weight:	318.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Caesalpinia decapetala
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Flavonoids Compound Library HO-1 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1417 mL	15.7085 mL	31.4169 mL	62.8338 mL	78.5423 mL
5 mM	0.6283 mL	3.1417 mL	6.2834 mL	12.5668 mL	15.7085 mL
10 mM	0.3142 mL	1.5708 mL	3.1417 mL	6.2834 mL	7.8542 mL
50 mM	0.0628 mL	0.3142 mL	0.6283 mL	1.2567 mL	1.5708 mL
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	0.6283 mL	0.7854 mL

CFN98869	Scillascillin	52706-07-7	312.3	C₁₇H₁₂O₆
CFN99209	7,3',4'-Trihydroxy-3-benzyl-2H-chromene	1111897-60-9	270.3	C₁₆H₁₄O₄
CFN92962	Episappanol	111254-18-3	304.29	C₁₆H₁₆O₆
CFN92769	4-O-Methylepisappanol	112529-37-0	318.3	C₁₇H₁₈O₆
CFN92771	3'-Deoxy-4-O-methylepisappanol	1052714-12-1	302.3	C₁₇H₁₈O₅
CFN92832	Sappanol	111254-19-4	304.3	C₁₆H₁₆O₆
CFN99068	4-O-Methylsappanol	104778-16-7	318.3	C₁₇H₁₈O₆
CFN92770	3'-Deoxy-4-O-methylsappanol	112408-68-1	302.3	C₁₇H₁₈O₅
CFN92964	Sappanone B	104778-15-6	302.28	C₁₆H₁₄O₆
CFN98844	2-Hydroxy-7-O-methylscillascillin	52096-50-1	342.3	C₁₈H₁₄O₇