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6'-O-Galloyl paeoniflorin
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Product Name 6'-O-Galloyl paeoniflorin
Price: $288 / 5mg
CAS No.: 122965-41-7
Catalog No.: CFN96175
Molecular Formula: C30H32O15
Molecular Weight: 632.57 g/mol
Purity: >=98%
Type of Compound: Monoterpenoids
Physical Desc.: Powder
Source: The roots of Paeonia lactiflora Pall.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
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Similar structural: Comparison
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Size /Price /Stock 10 mM * 1 mL in DMSO / $374.4 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress, GPF demonstrates a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 -), and the hydroxyl radical (•OH); GPF also can safeguarde HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins; GPF exerts its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species. GPF shows strong androgen receptor (AR) binding activity.
Targets: ROS | Androgen Receptor
In vitro:
Biomol. Ther., 2013, 21(5):349-57.
6'-o-galloylpaeoniflorin protects human keratinocytes against oxidative stress-induced cell damage.[Pubmed: 24244822 ]
6'-O-Galloyl paeoniflorin (GPF) is a galloylated derivate of paeoniflorin and a key chemical constituent of the peony root, a perennial flowering plant that is widely used as an herbal medicine in East Asia.
METHODS AND RESULTS:
This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical (•OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species.
CONCLUSIONS:
Taken together, these results indicate that GPF may be developed as a cytoprotector against ROS-mediated oxidative stress.
Chem. Pharm. Bull., 2009, 57(9):971-4.
Androgen modulators from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, Japan.[Pubmed: 19721258]
The monoterpene glycoside, 3'-O-galloylpaeoniflorin (1), and four known compounds, 6'-O-galloylalbiflorin (2), pentagalloylglucose (3), 6'-O-benzoylpaeoniflorin (4) and 6'-O-Galloyl paeoniflorin (5), were isolated from the roots of Paeonia lactiflora that had been grown and processed in Nara prefecture, Japan, as androgen modulators.
METHODS AND RESULTS:
Their structures were elucidated based on spectroscopic analysis. Compounds 2 and 3 showed strong androgen receptor (AR) binding activity (IC(50) values 33.7 and 4.1 microg/ml, respectively), 1, 4 and 5 showed weak activity (20, 31 and 12% at 120 microg/ml, respectively). However, paeoniflorin (6) and albiflorin (7), the structures of which are related to 1, 2, 4 and 5, showed no activity.
CONCLUSIONS:
These results suggested that both the structure of albiflorin and the galloyl moiety are important for 2 to show strong AR binding activity. Furthermore, compounds 1-5 inhibited growth of an androgen-dependent LNCaP-FGC (prostate cancer cell line), and were indicated to be AR antagonists. Compounds 2 and 3 might be candidates as safe, natural anti-androgens.
6'-O-Galloyl paeoniflorin Description
Source: The roots of Paeonia lactiflora Pall.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5809 mL 7.9043 mL 15.8085 mL 31.6171 mL 39.5213 mL
5 mM 0.3162 mL 1.5809 mL 3.1617 mL 6.3234 mL 7.9043 mL
10 mM 0.1581 mL 0.7904 mL 1.5809 mL 3.1617 mL 3.9521 mL
50 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.6323 mL 0.7904 mL
100 mM 0.0158 mL 0.079 mL 0.1581 mL 0.3162 mL 0.3952 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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